Okamoto Tetsuji

2019 - 2022 HBp17/FGFBPを制御するエクソソーム由来miRNAによる口腔癌治療の開発

2019 - 2022 Expression kinetics and pathological analysis study of T-cell suppressive ligand PD-L1 in oral cancer stem cell niche

2019 - 2022 無血清培養系における口腔癌患者由来活性化リンパ球からのiPS細胞の樹立と治療応用

2018 - 2021 Elucidation of regulatory chemical messengers in oral cancer stem cell niche and its diagnostic and therapeutic application

2018 - 2021 Analysis of the characteristics of Side Population cells derived from oral squamous cell carcinoma as cancer stem cells

2018 - 2021 Establishment study of liquid biopsy by isolation of circulating oral cancer cells in blood and analysis of their cell characteristics

2017 - 2020 Detection of bioactive substances from marine organisms targeting for candidates of driver mutation gene in oral cancer and applying them to drug design study

2017 - 2020 Development of gene therapy for oral cancer using Sendai virus vector with alpha2-antiplasmin gene

2016 - 2019 Clarification of the mechanism of oral carcinogenesis by the defect of degradation of chromosome passenger complex protein

2016 - 2019 Mechanism of pathogenesis and therapy development using tumor suppressor gene Pten abnormal Cowden syndrome iPS cells

2016 - 2019 Developmental study of oral cancer treatment using vitamin D derivative (ED-71) which is used for an osteoporosis treatment

2016 - 2018 Genomic surgery by genome editing of pathogenic mutant genes in oral maxillofacial disease-specific iPS cells

2015 - 2018 Functional Cytokine network in the Oral Cancer Stem Cell Niche and its applicastion for diagnosis and treatment

2015 - 2018 Analysis of cellular endocrinological properties of CD133-positive oral cancer-derived sphere in a serum-free suspension culture system

2014 - 2017 Purification, structure characterization of bioactive substances from marine organisms and application them to novel anti-oral cancer drugs with iPS cell research technique

2014 - 2017 Development of gene therapy for oral cancer with direct injection of Naked DNA of alpha2-antiplasmin gene

2014 - 2016 ヒト骨髄由来間葉系幹細胞を用いた安全・安心な細胞治療を行うための基盤整備研究

2014 - 2016 Induction of mandibular bone and tooth germ from embryo body formation form iPS cells in serum-, and feeder-free culture

2013 - 2016 Development of molecular target diagnosis and therapy targeted HBp17/FGFBP protein

2012 - 2015 Study on the prevention therapy for the invasion and metastasis of oral cancer by the suppression of E-cadherin processing

2012 - 2015 Elucidation of cytokine network in oral squamous cell carcinoma stem cell niche, and its application to diagnosis/treatment

2012 - 2015 Exploitation of MICA gene polymorphism for development of personalized medicine in oral cancer patients

2012 - 2015 Development research of new therapies targeting VEGF receptor that was expressed in oral cancer cells, and its signaling

2012 - 2014 Induction of Mandibular bone and tooth germ in embryo body formation from mouse and human iPS cells in serum-free cell culture

2011 - 2014 Radiation dosimetry and health effects of the residents living in the area of the Semipalatinsk nuclear test site and uranium mines

2011 - 2013 A base maintenance study to perform security and reliable cell treatment that used a human marrow origin mesenchymal cell.

2011 - 2013 Purification, structure characterization of bioactive substances from marine organisms and application them to the novel targeting oral cancer drugs

2011 - 2013 Study of the delivery system of nucleic acid medicines targeting cell adhesion molecules controlling the metastasis of oral cancer

2008 - 2012 A Molecular-epidemiological study of oral and maxillofacial disease among the residents living in Semipalatinsk nuclear test site in Kazakhstan

2010 - 2011 Induction of Jaw Bone and Tooth Germ from murine embryonic stem cells and human bone marrow stem cells in serum-free defined suspension culture

2009 - 2011 Isolation of molecules synthesized by stromal cells, which regulate tumor invasion and metastasis : application in diagnosis and therapy

2009 - 2011 Identification of Cancer Stem Cell and its niche system in Oral Cancer

2009 - 2011 Induction of tooth and craniofacial tissue from undifferentiated presumptive ectodermal Xenopus cell by aggregation culture method.

2009 - 2011 Exploitation of MICA gene polymorphism for development of personalized medicine in oral cancer patients

2008 - 2010 Low and low dose-rate risk estimation for the exposed people in Semipalatinsk nuclear test site

2008 - 2010 A base maintenance study to perform security and reliable cell treatment that used a human marrow origin mesenchymal cell.

2008 - 2010 Functional analysis of cholesterol synthetic pathway in osteochondrodysplasia of congenital cranio-maxillo-facial anomalies

2008 - 2010 Development research into molecular diagnosis and treatment method of carcinoma of the oral cavity targeting WNT signal system transfer factor group

2008 - 2010 Search for the bioactive compounds from the marine invertebrates and the basic study of application of them to novel anticancer drugs

2008 - 2009 E-カドヘリンプロセス分子のNaked DNAを用いた口腔癌の遺伝子治療法の開発

2008 - 2009 無血清再集合培養法を用いたマウスES細胞及びヒト骨髄幹細胞からの顎骨・歯胚誘導

2007 - 2008 口腔癌における癌幹細胞の分離・同定と同細胞を標的とした新しい診断・治療法の開発

2007 - 2008 Induction of tooth and craniofacial tissue from undifferentiated Xenopus ectoderm in vitro

2006 - 2007 Exploitation of MICA gene polymorphism for development of personalized medicine in oral cancer patients

2006 - 2007 Pulification, structure and characterization of anti-tumor compounds from marine organisms and analysis of their mechanisms

2006 - 2007 Development research into molecular target diagnosis and treatment method of cancer of oral cavity that makes Wnt signaling factor target

2006 - 2007 Proteomic analysis of molecular-targeted therapy against KGFR of salivary gland carcinomas

2006 - 2007 無血清再集合培養系を用いたマウスES及びヒト骨髄間葉系幹細胞からの顎骨・歯胚誘導

2004 - 2007 A Molecular-epidemiological Study of Oral and Maxillofacial Anomalies among the residents in Semipalatinsk Nuclear Test site in Kazakhstan

2005 - 2006 Search of Molecular Targets for Oral Cancer by Proteome Analysis and Its Application for Order-Made Therapy

2005 - 2006 Induction of madibular bone and tooth from bone marrow stem cells and its application to degenerative medicine

2005 - 2006 Induction of tooth from the activin A-treated Xenopus undifferentiated presumptive ectodermal cells.

2005 - 2006 Experimental study on the inhibition of invasion and metastasis of oral cancer by the suppression of processing of E-cadherin

2005 - 2006 Development of molecular target therapy to VEGF and VEGFR against oral cancer with RNAi methods

2004 - 2005 For growth factor-receptor system molecules target, a development study of genetic diagnosis and treatment in oral & maxilla-facial disease

2004 - 2005 Exploitation of MICA gene polymorphism for development of personalized medicine in oral cancer patients

2004 - 2005 予定外胚葉領域由来全能性幹(ES)細胞からの歯牙の誘導とその組織再生医療への応用

2003 - 2004 Search for Molecular Targets by Proteome Analysis and Its Use to Taylored-Made Therapy against Oral Cancer

2003 - 2004 Genetic diagnosis and therapy targeting the Wnt signaling pathway of oral cancer

2002 - 2004 External Dose Reconstruction of Radiation Exposure under Low Dose Rate in Long Term around Semipalatinsk Nuclear Weapon Test Site

2002 - 2003 Gene therapy targeting cell adhesion molecule that regulate metastasis of oral cancer

2002 - 2003 Suppression of angiogenesis in oral cancer by cyclooxygenase inhibitors

2002 - 2003 予定外胚葉領域由来全能性幹(ES)細胞からの歯牙の誘導とその組織再生医療への応用

2002 - 2002 FGF,FGF結合蛋白およびFGF受容体を標的とした扁平上皮癌の分子標的治療

2001 - 2002 Development of Gene diagnosis of Oral-Maxillofacial Deseases by Saliva-derived DNA

2001 - 2002 Development of targeting therapy using specific difference of lipid composition of oral cancer cell, resistant

2000 - 2002 Molecular Epidemiological studu of Oral and Maxillofacial disorders among the residents of the Semipalatinsk Nuclear Test Site Area

2001 - 2001 FGF、FGF結合蛋白およびFGF受容体を標的とした扁平上皮癌の分子標的治療

2001 - 2001 予定外胚葉領域由来全能性幹(ES)細胞からの歯牙の誘導とその組織再生医療への応用

2000 - 2001 Participation of Stromal component in Cancer Progression

2000 - 2001 Apoptosis induces of a multi-drug resistant oral cancer cells by Tax01, Alkaroid derived ICHI

1999 - 2000 Gene Diagnosis/Therapy of Oral Cancer Targetted for Autocrine Growth Factor and Angiogenic Factor Genes

1999 - 2000 Development of photodynamic therapy to early stage oral cancer using drug delivery system

1999 - 2000 Gene Diagnosis and Therapy of Salivary Gland Tumors Targetted for FGFR genes

1999 - 2000 A study of the new drug delivery system using liposome of the same lipid composition as oral cancer cell membrane

1999 - 2000 セリンプロテアーゼ阻害剤を用いた口腔癌転移に対する薬物療法

1999 - 1999 FGF結合蛋白(FGFBP/HBp17)を標的とした扁平上皮癌の分子標的治療

1999 - 1999 神経・内分泌・免疫ネットワーク間の情報伝達液性因子を用いた新しいストレス定量法

1998 - 1999 New targeting therapy with complex of liposome, consist of comparable lipid composition of oral cancer cells, and anti-EGF receptor antibody.

1998 - 1999 Induction of apoptpsis in multi-drug resistant oral cancer cells using Taxol alkaroid derived from Taxaceae

1997 - 1998 Expressionand Regulation of Autocrineand Angiogenic Factors produced by Oral Cancer

1997 - 1998 Developmentofan New Implant System Attached with Tissue Engineered Periodontal-Ligament

1996 - 1997 Development of new drug deliverty system with liposome consist of comparable to the lipid composition of oral cancer cancer cell membrane

1996 - 1996 ヒト唾液腺腫瘍の悪性転換過程におけるFGF受容体遺伝子群のディファレンシャル発現

1995 - 1996 A STUDY OF GENETHERAPY AGAINST ORAL CANCER TARGETTED TO THE GENE OF AUTOCRINE GROWTH FACTOR

1995 - 1995 口腔癌の産生する血管新生因子とその制御による治療への応用

1994 - 1995 Adoptive immunotherapy with LAK cells conjugated with epidermal growth factor receptor antibody

1994 - 1995 Sensitivities to Various anti-Cancer Drug of Oral Cancer Cells in Seram-free Culture.-Does Membrane Lipid Composition determine the Sentitivity-

1992 - 1993 New drug delivery system for cancer chemotherapy using lipid commpositions characteristic of cancer cell membrane

1991 - 1992 Inhibitors of cytotoxic T cell activities produced by cultured tumor cells.

1990 - 1991 Novel cancer therapy using human monoclonal antibody against human epidermal growth factor receptor

1989 - 1990 Autocrine Growth Factor Produced by Oral Cancer