Research theme for competitive and other funds (7)：
2023 - 2026 抗体遺伝子再編成の制御による迅速、確実な試験管内抗体創出と親和性成熟
2020 - 2023 DNA脱メチル化酵素による抗体遺伝子再編成制御メカニズムの解析
2019 - 2023 二重特異性を有する完全ヒト抗体の迅速取得とそのシームレスな最適化
2016 - 2018 超高親和性抗体の高効率作製技術及びその自動化装置の開発
2014 - 2016 Development of the technology to rapidly generate bispecific antibodies.
2009 - 2010 NEU3を創薬ターゲットとした癌治療用候補抗体の開発
2004 - 2004 相同組換え活性化による新規試験管内抗体作製法の開発
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Papers (15)：
Hitomi Masuda, Atsushi Sawada, Shu-ichi Hashimoto, Kanako Tamai, Ke-Yi Lin, Naoto Harigai, Kohei Kurosawa, Kunihiro Ohta, Hidetaka Seo, Hiroshi Itou. Fast-tracking antibody maturation using a B cell-based display system. MABS. 2022. 14. 1
Hidetaka Seo, Hitomi Masuda, Kenjiro Asagoshi, Tomoaki Uchiki, Shigehisa Kawata, Goh Sasaki, Takashi Yabuki, Shunsuke Miyai, Naoki Takahashi, Shu-Ichi Hashimoto, et al. Streamlined human antibody generation and optimization by exploiting designed immunoglobulin loci in a B cell line. Cellular & molecular immunology. 2021. 18. 6. 1545-1561
Natsuki Takamura, Hidetaka Seo, Kunihiro Ohta. TET3 dioxygenase modulates gene conversion at the avian immunoglobulin variable region via demethylation of non-CpG sites in pseudogene templates. Genes to cells : devoted to molecular & cellular mechanisms. 2021. 26. 3. 121-135
Hashimoto K, Kurosawa K, Seo H, Ohta K. Rapid Chimerization of Antibodies. Methods in molecular biology (Clifton, N.J.). 2019. 1904. 307-317
