Okada Takashi

オカダタカシ | Okada Takashi

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.ims.u-tokyo.ac.jp/imsut/jp/index.php

Research field (3)： Neurosurgery , Virology , Pathobiochemistry

Research keywords (9)：筋病学 , 分子生物学 , 腫瘍学 , 脳神経外科学 , 遺伝子治療 , Molecular Biology , Oncology , Neurosurgery , Gene Therapy

Research theme for competitive and other funds (28)：

2024 - 2029 アデノ随伴ウイルスベクター基盤技術開発と脳神経疾患に対する遺伝子細胞療法
2020 - 2025 アデノ随伴ウイルスベクター基盤技術開発と脳神経疾患に対する遺伝子細胞療法
2019 - 2022 Integrated understanding of dermatan sulfate through uncovering pathophysiology of musculocontractural Ehlers-Danlos syndrome
2017 - 2019 Direct reprogramming for the differentiation into retinal ganglion cells by gene transfection
2016 - 2019 LATmiRNA

2015 - 2019 Effect of Dental Pulp Stem Cells Overexpressing Therapeutic Gene in a Rat Stroke Model.

2014 - 2019 AAV vector-mediated cell and gene therapy for neuronal disease

2014 - 2017 Development of rAAV-mediated brain transduction with transient ultrasound-mediated modulation of the blood-brain interface in adult common marmoset toward modeling epilepsy

2013 - 2016 Development of AAV-induced exonskipping therapy for Duchenne muscular dystrophy

2012 - 2015 Gene correction therapy by homologous recombination

2011 - 2015 Systematic functional mapping of synaptic connections between cerebral cortical areas

2011 - 2015 Model animals by nonhuman primate for Alzheimer disease, hyper expression of mutant amyloid precursor protein and formation of senile plaques in the brain

2010 - 2015 AAV vector-mediated cell and gene therapy for neuronal diseases

2013 - 2014 AAV中空粒子を用いる臓器特異的DDSの臨床応用に向けた開発

2010 - 2012 Optogenetic control of macaque temporal neurons

2010 - 2012 A study toward development of novel Alzheimer therapies based on the regulation ofβ-secretase function

2007 - 2009 AAV vector-mediated cell and gene therapy for neuronal diseases

2007 - 2009 糖鎖情報を利用したがん幹細胞マーカーの探索と腫瘍標的システム

2005 - 2009 Development of AAV (adeno-associated virus) vectors and their application to cancer therapy

2004 - 2006 Gene therapy for neuronal diseases using rAAV

2003 - 2004 神経幹細胞への染色体部位特異的遺伝子組込み法の開発

2001 - 2004 腫瘍選択的増幅型ハイブリッドウイルスベクターの開発とその制御機構の解明

2002 - 2003 Development of basic technologies for gene therapy using adeno-associated virus (AAV)

2001 - 2002 Research for genetic enhanced immunotherapy to the human malignant glioma.

2001 - 2002 悪性神経膠腫に対する腫瘍特異的増幅型ハイブリッドベクターを用いた遺伝子治療

2002 - Gene thrapy for Lifestyle- related diseases

1999 - 2001 Gene transfer into hematopoietic stem cells and gene therapy for chronic granulomatous disease

Vector Development for Gene Therapy

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Papers (182)：

Makusu Tsutsui, Mikako Wada, Akihide Arima, Yuji Tsunekawa, Takako Sasaki, Kenji Sakamoto, Kazumichi Yokota, Yoshinobu Baba, Tomoji Kawai, Takashi Okada. Identifying Viral Vector Characteristics by Nanopore Sensing. ACS nano. 2024
Yae Kurosawa, Yuji Tsunekawa, Mikako Wada, Yuko Aizen, Yuko Nitahara-Kasahara, Takashi Okada. Purification of Adeno-Associated Viral Vector Serotype 9 Using Ceramic Hydroxyapatite Chromatography and its Analysis. Current protocols. 2024. 4. 6. e1068
Kiichi Hirohata, Yuki Yamaguchi, Takahiro Maruno, Risa Shibuya, Tetsuo Torisu, Takayuki Onishi, Hideto Chono, Junichi Mineno, Yuan Yuzhe, Kiyoko Higashiyama, et al. Applications and Limitations of Equilibrium Density Gradient Analytical Ultracentrifugation for the Quantitative Characterization of Adeno-Associated Virus Vectors. Analytical chemistry. 2024. 96. 2. 642-651
Yuko Nitahara-Kasahara, Guillermo Posadas-Herrera, Kunio Hirai, Yuki Oda, Noriko Snagu-Miyamoto, Yuji Yamanashi, Takashi Okada. Characterization of disease-specific alterations in metabolites and effects of mesenchymal stromal cells on dystrophic muscles. Frontiers in cell and developmental biology. 2024. 12. 1363541-1363541
Kouhei Yoshida, Yuji Tsunekawa, Kento Kurihara, Kazuya Watanabe, Yuriko Makino-Manabe, Mikako Wada, Toru Tanaka, Teruhiko Ide, Takashi Okada. Engineering a highly durable adeno-associated virus receptor for analytical applications. Molecular therapy. Methods & clinical development. 2023. 31. 101157-101157

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MISC (213)：

喜納(早下)裕美, 笠原優子, 岡田尚巳. Gene and cell therapy for Duchenne muscular dystrophy. 金沢大学十全医学会雑誌. 2024. 133. 1
笠原優子, 倉岡睦季, 木村公一, 峰岸かつら, 林真広, 中石智之, 上田恭義, 青木吉嗣, 岡田尚巳. 羊膜間葉系間質細胞を用いた筋ジストロフィーモデル動物における治療評価. 日本再生医療学会総会(Web). 2024. 23rd
仁藤智香子, 高橋史郎, 荒川将史, 古寺紘人, 宮川世志幸, 岡田尚巳, 木村和美. 間葉系幹細胞を応用した脳神経疾患に対する炎症制御療法. 脳循環代謝(Web). 2023. 35. 1
喜納(早下)裕美, 岡田尚巳. 遺伝子治療 6.AAVベクターを用いた遺伝子治療脊髄性筋萎縮症・筋ジストロフィー症. 日本医師会雑誌. 2023. 152
喜納(早下)裕美, 岡田尚巳. 筋ジストロフィーに対する遺伝子細胞治療. MD Frontier. 2023. 3. 1

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Patents (47)：

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Books (1)：

Adeno-associated viral vector-mediated gene therapy of ischemia-induced neuronal death. Methods Enzymol. Vol 346: Gene Therapy Methods (ed. by M. Ian Phillips)
Academic Press 2002 ISBN:0121822478

Education (2)：

- 1995 Kanazawa University
- 1991 Kanazawa University

Professional career (1)：

PhD (Kanazawa University)

Work history (10)：

2020 - 現在東京大学医科学研究所, 遺伝子・細胞治療センターセンター長
2019 - 現在 The Institute of Medical Science, The University of Tokyo Division of Molecular and Medical Genetics Professor
2014 - 2019 NIPPON MEDICAL SCHOOL, professor
2013 - 2014 国立精神・神経医療研究センター病院脳神経外科併任医師
2007 - 2014 NCNP section chief

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Committee career (8)：

- 現在 PMDA 科学委員会(ゲノム編集専門部会) 委員
- 現在日本人類遺伝学会臨床遺伝専門医
- 現在日本脳神経外科学会脳神経外科専門医
- 現在国際協力遺伝病遺伝子治療フォーラム幹事
- 現在日本生化学会代議員

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Awards (2)：

2010 - 日本遺伝子治療学会遺伝子治療研究奨励賞
2005 - 日本癌学会奨励賞

Association Membership(s) (9)：

国際協力遺伝病遺伝子治療フォーラム , 日本ウイルス学会 , 日本分子生物学会 , 日本脳神経外科学会 , 日本癌学会 , 日本遺伝子治療学会 , ASGCT , 日本人類遺伝学会 , 日本生化学会

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