Research field (3):
Tumor biology
, Medical biochemistry
, Molecular biology
Research keywords (3):
分子腫瘍学
, ゲノム医科学
, 分子生物学
Research theme for competitive and other funds (11):
2025 - 2028 組織特異的ヒトボカウイルスベクターの開発
2025 - 2028 BAP1機能喪失腫瘍の特徴と治療戦略
2024 - 2027 Development of novel cancer therapy based on the characteristics of epigenetic leaders that are upregulated in tumors
2024 - 2027 Network analysis method for extracting useful molecules in HFLAC
2020 - 2023 Understanding of Wnt-addicted cancer cells using comprehensives transcriptome data
2019 - 2022 Elucidating the significance of amplified expression of endogenous retrotransposon in autoimmune/autoinflammatory diseases
2017 - 2020 Targeting novel bromodomain protein in colorectal cancer
2017 - 2020 Elucidation of mechanisms underlying colorectal tumorigenesis associated with deregulation of new Wnt targets
2014 - 2016 Functional analysis of a novel bromodomain protein in cancer cells
2011 - 2014 Functional analysis of a histone methyltransferase in colorectal cancer by comprehensive genome analysis
2011 - 2012 Development of novel cancer therapy through the targeting bromodomain protein
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Papers (125):
Megumi Yamaji, Tomomi Nakahara, Tomoko Nakanishi, Satomi Aoyama-Kikawa, Kiyoshi Yamaguchi, Yoichi Furukawa, Mariko Nakamura, Tadashi Okada, Hirotaka Tabata, Ryoko Fuse, et al. Disruption of Human Papillomavirus 16 E6/E7 Genes Using All-in-One Adenovirus Vectors Expressing Eight Double-Nicking Guide RNAs. International Journal of Molecular Sciences. 2025. 26. 17. 8685-8685
Takahiro Kamiya, Masahiko Ajiro, Motohiko Oshima, Shuhei Koide, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Akiho Tsuchiya, Satoshi Kaito, Naoki Itokawa, Ryoji Ito, et al. Identification of a CD138-negative therapy-resistant subpopulation in multiple myeloma with vulnerability to splicing factor inhibition. Blood Cancer Discovery. 2025
Xia Yang, Yun-Zhong Nie, Chun Lu, Yang Li, Yoshihito Hayashi, Riana Plummer, Na Luo, Qinglin Li, Toshiharu Kasai, Takashi Okumura, et al. Human pluripotent stem cell-derived fetal hepatic stellate cells promote vascularization and maturation in liver organoids. Developmental Cell. 2025
Atsuhiro Arisue, Kiyoshi Yamaguchi, Kiyoko Takane, Yoshiko Asakura, Yasushi Hasegawa, Masaru Mizuno, Hiroyuki Nitta, Kazuyuki Ishida, Takeshi Iwaya, Eigo Shimizu, et al. Mutual Tissue Microchimerism of Hepatoblastomas in Monozygotic Twins From a Familial Adenomatous Polyposis Family. Twin Research and Human Genetics. 2025. 1-9
Yue Zhang, Teh-Wei Wang, Maho Tamatani, Xinyi Zeng, Lindo Nakamura, Satotaka Omori, Kiyoshi Yamaguchi, Seira Hatakeyama, Eigo Shimizu, Satoshi Yamazaki, et al. Signaling networks in cancer stromal senescent cells establish malignant microenvironment. Proceedings of the National Academy of Sciences. 2025. 122. 14
池上 恒雄, 寺門 侑美, 劉 洵, 高根 希世子, 山口 貴世志, 古川 洋一. Kras活性化とPten不活化による状況依存的なマウス肝腫瘍の誘導(Context-dependent induction of distinct liver tumors in mice with Kras activation and Pten inactivation). 日本癌学会総会記事. 2018. 77回. 402-402
山口 貴世志, 清水 英悟, 池上 恒雄, 高根 希世子, 山口 類, 井元 清哉, 宮野 悟, 古川 洋一. ポリメラーゼ校正関連ポリポーシス患者由来の大腸腫瘍の遺伝子およびエピゲノム解析(Genetic and epigenetic analyses of colorectal tumors in a patient with the loss of polymerase proofreading). 日本癌学会総会記事. 2018. 77回. 1798-1798
Saku Akari, Yamaguchi Kiyoshi, Ikenoue Tsuneo, Fujiyuki Tomoko, Yoneda Misako, Hata Hiroko, Oyama Masaaki, Kai Chieko, Furukawa Yoichi. Elucidation of transcriptional regulation mechanism of PVRL4, a receptor for oncolytic measles virus. CANCER SCIENCE. 2018. 109. 979