Rchr
J-GLOBAL ID:200901041990366531
Update date: Oct. 26, 2021
Higaki Katsumi
ヒガキ カツミ | Higaki Katsumi
Affiliation and department:
Job title:
assistant Professor,associate professor
Research field (5):
Fetal medicine/Pediatrics
, Medical biochemistry
, Cell biology
, Neuroscience - general
, Neuroanatomy and physiology
Research keywords (7):
Lysosomal disease
, 神経変性疾患
, 脂質
, 細胞生物学
, Lipids
, Cell Biology
, Neurodegenerative disorder
Research theme for competitive and other funds (12):
- 2017 - 2019 ムコ多糖症の脳病態に有効な新規シャペロン化合物の探索
- 2017 - GM1-ガングリオシドーシス脳病態に有効な新規低分子シャペロン治療薬の探索
- 2017 - ライソゾーム病(ファブリ病を含む)に関する調査研究
- 2014 - 2016 転写因子TFEBを介したライソゾーム病細胞病態の解析と新規治療法の開発
- 2011 - 2013 ライソゾーム病に対するケミカルシャペロン療法の細胞内分子機構の解明
- 2008 - 2010 マイクロアレイ解析を用いたライソゾーム病神経変性に対する新規分子標的療法の開発
- 2006 - 2007 神経栄養因子を用いたリソソーム蓄積症神経変性治療法の開発
- 2004 - 2005 銅を標的としたニーマン・ピック病C型の治療法の開発
- 2003 - 2004 Analysis of GMI-gangliosidosis
- 2003 - 2004 Analysis of Niemann-Pich type C disease.
- 1996 - 2004 Niemann-Pick C disease
- 2001 - 2001 ニーマン・ピック病C型原因遺伝子の単離と機能解析
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Papers (48):
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Gonzalez-Cuesta M, Goyard D, Nanba E, Higaki K, Garcia-Fernandez JM, Renaudet O, Mellet CO. Multivalent glycolignads with lectin/enzyme dual specificity: self-deliverable glycosidase regulators. ChemComm. 2019. 55. 12845-12848
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Ikuno M, Yamakado H, Akiyama H, Parajuli LK, Taguchi K, Hara J, Uemura N, Hatanaka Y, Higaki K, Ohno K, et al. GBA haploinsufficiency accelerates alpha synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson’s disease. Hum Mol Genet. 2019. 28. 1894-1904
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Risquez-Cuadro R, Matsumoto R, Caballero FO, Nanba E, Higaki K, Garcia-Fernandez JM, Mellet CO. Multipoint enzyme inhibition in a medicinal chemistry cintext: pharmacological chaperones for the treatment of a-Mannosidosis. J Med Chem. 2019. 62. 5832-5843
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Mena-Barragán T, García-Moreno MI, Sevsek A, Okazaki T, Nanba E, Higaki K, Martin MI, Pieters RJ, García Fernández JM, Ortiz Mellet C. Probing the inhibitor versus chaperone properties of sp2-iminosugars towards human b-glucocerebrosidase: a picomolar chaperone for Gaucher disease. Molecules. 2018
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M. Isabel Garcia-Moreno, Mario de la Mata, Elena M. Sanchez-Fernandez, Juan M. Benito, Antonio Diaz-Quintana, Santos Fustero, Eiji Nanba, Katsumi Higaki, Jose A. Sanchez-Alcazar, Jose M. Garcia Fernandez, et al. Fluorinated Chaperone-beta-Cyclodextrin Formulations for beta-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease. JOURNAL OF MEDICINAL CHEMISTRY. 2017. 60. 5. 1829-1842
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MISC (18):
Patents (1):
Lectures and oral presentations (5):
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Development of pharmacological chaperone therapy for lysosomal storage diseases
(2nd Asia-Pacific Lysosomal Conference 2019)
-
ワークショップ-神経変性疾患への分子生物学的アプローチ「ライソゾーム病に対する薬理シャペロン療法」
(2017年度生命科学系学会合同年次会 2017)
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Symposium- Therapy for Genetic Diseases “Chaperone therapy for lysosomal storage diseases”
(13th International Congress for Human Genetics 2016)
-
先端分野講演I「シャペロン療法の最新状況」
(第21回日本ライソゾーム病研究会 2016)
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Morquio B research: chaperone therapy
(3rd Annual Morquio Conference 2015)
Education (6):
Professional career (2):
- Ph. D. (Tottori University)
- Doctor of Lifesciences(Ph.D) (Tottori University)
Work history (9):
- 2018/04 - 現在 Research Initiative Center, Organization for Research Initiative and Promotion, Tottori University Associate Professor
- 2004/04 - 2018/03 Center for Bioscience and technology, Tottori University Associate Professor
- 2004 - 2018 Center for Biosci Tech, Tottori University. Associate Professor
- 2003 - 2004 Tottori University Research Center for Bioscience and Technology
- 2003 - 2004 Center for Biosci Tech Tottori University Assistant Professor
- 2001 - 2003 Columbia University
- 2001 - 2003 Columbia University Post-Doctoral Research Fellow,
- 1997 - 2001 Tottori University Faculty of Medicine
- 1997 - 2001 Research Associate, Faculty of Medicine,
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Awards (4):
- 2013 - 鳥取大学 研究業績表彰(日の丸賞)
- 2011 - 武田科学振興財団 医学系研究奨励
- 2011 - 日本先天代謝異常学会 奨励賞
- 2008 - 日本ライソゾーム病研究会 奨励賞
Association Membership(s) (5):
日本生化学会
, 日本人類遺伝学会
, Japanese Society of Biochemistry
, Japanese Society of Human Genetics
, JAPANESE SOCIETY FOR INHERITED METABOLIC DISEASES
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