Hayakawa Makio

ハヤカワマキオ | Hayakawa Makio

Affiliation and department：
Job title： Professor

Research field (2)： Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (4)：衛生化学 , 細胞生物学 , 分子生物学 , Molecular cell Biology

Research theme for competitive and other funds (3)：

発がん・がん転移
酸素ストレスと情報伝達
Redox signaling

Papers (53)：

Tomofumi Fujino, Kouta Sugizaki, Rei Kato, Masaki Beppu, Satoshi Murakami, Hyunjung Lee, Toshiyuki Oshima, Makio Hayakawa. Farnesoid x receptor and liver x receptors regulate oct3/4 expression by multiple feedback regulating system in normal renal-derived cells and renal adenocarcinoma cells. Journal of Toxicological Sciences. 2020. 45. 1. 25-35
Tomofumi Fujino, Akihito Yokosuka, Harutaka Ichikawa, Toshiyuki Oshima, Yoshihiro Mimaki, Makio Hayakawa. AU-1 from Agavaceae plants downregulates the expression of glycolytic enzyme phosphoglycerate mutase. Journal of Natural Medicines. 2018. 72. 1. 342-346
Tomofumi Fujino, Ryosuke Sakamaki, Haruka Ito, Yumiko Furusato, Nami Sakamoto, Toshiyuki Oshima, Makio Hayakawa. Farnesoid X receptor regulates the growth of renal adenocarcinoma cells without affecting that of a normal renal cell-derived cell line. JOURNAL OF TOXICOLOGICAL SCIENCES. 2017. 42. 3. 259-265
Tomofumi Fujino, Akihito Yokosuka, Hideaki Higurashi, Rina Yokokawa, Ryo Sakurai, Wataru Harashima, Yuichi Miki, Yasuyuki Fujiwara, Yoshihiro Mimaki, Makio Hayakawa. AU-1 from Agavaceae plants causes transient increase in p21/Cip1 expression in renal adenocarcinoma ACHN cells in an miR-34-dependent manner. JOURNAL OF NATURAL MEDICINES. 2017. 71. 1. 36-43
Tomofumi Fujino, Akiko Maruko-Ohtake, Yosuke Ohtake, Tomonori Kobayashi, Ken Ando, Airi Takeuchi, Yasuhito Ohkubo, Makio Hayakawa. Farnesoid X receptor knockdown provides significant growth inhibition in hepatocellular carcinoma cells while it does not interfere with the proliferation of primary human hepatocyte-derived cells. JOURNAL OF TOXICOLOGICAL SCIENCES. 2015. 40. 4. 501-508

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MISC (21)：

Tomofumi Fujino, Rina Yokokawa, Toshiyuki Oshima, Makio Hayakawa. SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent manner. Journal of Toxicological Sciences. 2018. 43. 12. 711-715
石原舞, 黒田明平, 井口巴樹, 米山由里香, 藤野智史, 早川磨紀男, 梅村直己, 坂上宏, 三巻祥浩. Thevetia neriifolia種子のカルデノリド配糖体と腫瘍細胞毒性(2). 日本薬学会年会要旨集(CD-ROM). 2015. 135th
黒田明平, 松尾侑希子, 久保聡, 藤野智史, 早川磨紀男, 三巻祥浩. ジギタリス種子由来のカルデノリド配糖体の腫瘍選択的細胞毒性とその作用メカニズムについて. 天然薬物の開発と応用シンポジウム講演要旨集. 2014. 20th
T. Fujino, C. Tamura, M. Kuroda, S. Kubo, H. Higurashi, N. Sakamoto, Y. Mimaki, M. Hayakawa. Cardenolide glycosides from the seeds of Digitalis purpurea exhibit specific cytotoxicity towards adenocarcinoma and hepatocellular carcinoma cells. MOLECULAR BIOLOGY OF THE CELL. 2013. 24
藤野智史, 田村実子, 黒田明平, 久保聡, 日暮秀成, 坂本奈美, 三巻祥浩, 早川磨紀男. ジギタリス種子より単離されたカルデノリド配糖体はヒト腎癌・肝癌細胞に対し癌細胞選択的な細胞毒性を有する. 日本分子生物学会年会プログラム・要旨集(Web). 2013. 36th

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Lectures and oral presentations (4)：

FXRは肝細胞において肝細胞増殖因子(HGF)によりERK依存的に down-regulate される
(脂質生化学研究 2008)
HIFα以外の因子が Hypoxia に曝された肝細胞におけるFXR活性低下に関与する
(脂質生化学研究 2007)
低酸素ストレスにさらされた肝細胞におけるコレステロール代謝に関わる核内受容体 farnesoid X receptor の機能解析
(脂質生化学研究 2006)
Hypoxia に曝された肝細胞におけるFXR活性低下ならびに胆汁酸トランスポーター発現低下に対するHIF-1αの関与
(脂質生化学研究 2005)

Education (2)：

- 1985 The University of Tokyo Faculty of Pharmaceutical Sciences Department of Pharmacy
- 1985 The University of Tokyo Faculty of Pharmaceutical Science

Professional career (2)：

(BLANK) (The University of Tokyo)
(BLANK) (The University of Tokyo)

Work history (4)：

1996 - 1998 カリファルニア大学サンディエゴ校ポスドク
1996 - 1998 Post Doctoral Fellow at University of California., Saupiego
1987 - 1996 Setsunan University Faculty of Pharmaceutical Sciences
1987 - 1996 Research Assistant at Setsunan Unirersity

Association Membership(s) (3)：

日本分子生物学会 , 日本薬学会 , 日本生化学会

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