Tsunoda Shin-ichi

ツノダシンイチ | Tsunoda Shin-ichi

Affiliation and department：
Job title： Professor
Other affiliations (1)：

国立研究開発法人医薬基盤・健康・栄養研究所客員研究員

Research field (1)： Pharmaceuticals - health and biochemistry

Research theme for competitive and other funds (23)：

2022 - 2025 2型TNF受容体を介する免疫制御機構の解明とがん免疫療法への応用
2021 - 2024 免疫難病治療の新規モダリティを目指したTNFR1シグナル選択的阻害薬の創製
2020 - 2023 浮遊粒子状物質によるインフラマソーム活性化におけるレドックス制御の仕組みの解明
2018 - 2021 Molecular design of immunocytokines for control of regulatory T cell function
2018 - 2021 Study of TNFR2-APP3 signaling pathway and and its immuno-suppressive function

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Papers (129)：

Takashi Tadokoro, Harumi Tsuboi, Kota Nakamura, Tetsushi Hayakawa, Reo Ohmura, Izumi Kato, Masaki Inoue, Shin-Ichi Tsunoda, Sayaka Niizuma, Yukari Okada, et al. Thermostability and binding properties of single-chained Fv fragments derived from therapeutic antibodies. Protein science : a publication of the Protein Society. 2024. 33. 7. e5084
Masaki Inoue, Yuta Tsuji, Ayaka Kashiwada, Asahi Yokoyama, Akane Iwata, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda. An immunocytokine consisting of a TNFR2 agonist and TNFR2 scFv enhances the expansion of regulatory T cells through TNFR2 clustering. Biochemical and Biophysical Research Communications. 2024
Masaki Inoue, Kanako Yamashita, Yuta Tsuji, Midori Miki, Shota Amano, Taichi Okumura, Koki Kuge, Takao Tone, Shota Enomoto, Chinatsu Yoshimine, et al. Characterization of a TNFR2-Selective Agonistic TNF-α Mutant and Its Derivatives as an Optimal Regulatory T Cell Expander. The Journal of Immunology. 2021. 206. 8. 1740-1751
Higashisaka K, Nakashima A, Iwahara Y, Aoki A, Nakayama M, Yanagihara I, Lin Y, Nagano K, Tsunoda SI, Saito S, et al. Neutrophil Depletion Exacerbates Pregnancy Complications, Including Placental Damage, Induced by Silica Nanoparticles in Mice. Frontiers in immunology. 2018. 9. 1850
Takashi Nagano, Kazuya Nagano, Hiromi Nabeshi, Tokuyuki Yoshida, Haruhiko Kamada, Shin-ichi Tsunoda, Jian-Qing Gao, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi. Modifying the Surface of Silica Nanoparticles with Amino or Carboxyl Groups Decreases Their Cytotoxicity to Parenchymal Hepatocytes. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2017. 40. 5. 726-728

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MISC (51)：

大須賀絵理, 大須賀絵理, 長野一也, 長野一也, 森宣瑛, 森宣瑛, 永野貴士, 永野貴士, 向井美穂, 向井美穂, et al. 非免疫ウサギファージ抗体ライブラリの構築と動物種によるモノクローナル抗体の特性評価. 日本薬学会年会要旨集(CD-ROM). 2016. 136th
向井美穂, 向井美穂, 長野一也, 長野一也, 森宣瑛, 森宣瑛, 永野貴士, 永野貴士, 大須賀絵理, 大須賀絵理, et al. HHV-6B感染症に対する治療法の開発に向けたCD134中和抗体の創製. 日本薬学会年会要旨集(CD-ROM). 2016. 136th
芳賀優弥, 芳賀優弥, 長野一也, 長野一也, 森宣瑛, 森宣瑛, 永野貴士, 永野貴士, 向井美穂, 向井美穂, et al. がん分子病態の解明を目指したがん患者由来抗体ライブラリの構築と評価. 日本薬学会年会要旨集(CD-ROM). 2016. 136th
森宣瑛, 森宣瑛, 長野一也, 長野一也, 永野貴士, 永野貴士, 向井美穂, 向井美穂, 大須賀絵理, 大須賀絵理, et al. 短期間での高親和性抗体取得に向けた免疫方法の最適化. 日本薬学会年会要旨集(CD-ROM). 2016. 136th
井阪亮, 井阪亮, 長野一也, 長野一也, 森宣瑛, 森宣瑛, 永野貴士, 永野貴士, 向井美穂, 向井美穂, et al. 細胞内可溶性発現抗体を鋳型としたイントラボディライブラリの構築と評価. 日本薬学会年会要旨集(CD-ROM). 2016. 136th

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