Art

J-GLOBAL ID：201702245549996876   Reference number：17A0777221

Modifying the Surface of Silica Nanoparticles with Amino or Carboxyl Groups Decreases Their Cytotoxicity to Parenchymal Hepatocytes

アミノ基またはカルボキシル基によるシリカナノ粒子表面の修飾は実質肝細胞に対するその細胞毒性を低下させる

Author (15)： Nagano Takashi (Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University) ,  Nagano Kazuya (Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University) ,  Nabeshi Hiromi (Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University) ,  Yoshida Tokuyuki (Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University) ,  Kamada Haruhiko (Laboratory of Biopharmaceutical Research, National Institutes of Biomedical Innovation, Health and Nutrition) ,  Kamada Haruhiko (The Center for Advanced Medical Engineering and Informatics, Osaka University) ,  Tsunoda Shin-ichi (Laboratory of Biopharmaceutical Research, National Institutes of Biomedical Innovation, Health and Nutrition) ,  Tsunoda Shin-ichi (The Center for Advanced Medical Engineering and Informatics, Osaka University) ,  Gao Jian-Qing (Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University) ,  Higashisaka Kazuma (Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University) ,  Yoshioka Yasuo (Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University) ,  Yoshioka Yasuo (Vaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University) ,  Yoshioka Yasuo (BIKEN Center for Innovative Vaccine Research and Development, The Research Foundation for Microbial Diseases of Osaka University) ,  Tsutsumi Yasuo (Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University) ,  Tsutsumi Yasuo (The Center for Advanced Medical Engineering and Informatics, Osaka University)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 40  Issue： 5  Page： 726-728(J-STAGE)  Publication year： 2017 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...

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Author keywords (6)： surface-modification ,  liver damage ,  safety assessment ,  surface-modification ,  liver damage ,  safety assessment

JST classification (1)： Toxicology in general  (GZ01000K)

Reference (14)：

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• 4) Knopp D, Tang D, Niessner R. Review: bioanalytical applications of biomolecule-functionalized nanometer-sized doped silica particles. Anal. Chim. Acta, 647, 14-30 (2009).
• 5) Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Arimori A, Isobe M, Tochigi S, Kondoh S, Hirai T, Akase T, Yamashita T, Yamashita K, Yoshida T, Nagano K, Abe Y, Yoshioka Y, Kamada H, Imazawa T, Itoh N, Kondoh M, Yagi K, Mayumi T, Tsunoda S, Tsutsumi Y. Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure. Nanotechnology, 23, 045101 (2012).

Terms in the title (6)： アミノ基 ,  カルボキシル基 ,  シリカナノ粒子 ,  修飾 ,  肝細胞 ,  細胞毒性