Rchr
J-GLOBAL ID：200901060667258686   Update date: Apr. 06, 2022

Sabe Hisataka

サベ ヒサタカ | Sabe Hisataka
Affiliation and department：
Hokkaido University Graduate School of Medicine

About Hokkaido University Graduate School of Medicine


Job title： Professor
Homepage URL  (2)： http://g21001.med.hokudai.ac.jp/ ,  http://g21001.med.hokudai.ac.jp/index-e.html
Research field  (1)： Medical biochemistry
Research keywords  (25)： インテグリン ,  細胞運動 ,  細胞接着 ,  浸潤 ,  シグナル伝達 ,  Arf6 ,  カドヘリン ,  endocytosis ,  乳癌 ,  p130Cas ,  AMAP1 ,  E-cadherin ,  接触阻止 ,  癌細胞 ,  endosomal recycling ,  ARF ,  単球細胞 ,  癌浸潤 ,  GEP100 ,  マクロファージ ,  転移 ,  チロシンリン酸化 ,  ArfGAP ,  分子細胞生物学 ,  Molecular Cell Biology
Research theme for competitive and other funds  (37)：
  • 2018 - 2021 上皮integrity維持機構多様性の生物学的意義の解明
  • 2015 - 2017 Mechansim by which Arf6 protein becomes overexpressed in cancer to promote malignancy
  • 2014 - 2017 The identification of targeting molecules for EMT-activating signals from ErbB family receptor in lung cancer
  • 2014 - 2017 TP53 mutation drives cancer IR-resistance via the Arf6-based pathway
  • 2013 - 2016 Roles of ARFs in superoxide production and chemotaxis of neutrophil
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Papers (132)：
  • Mei Horikawa, Hisataka Sabe, Yasuhito Onodera. Strategies for all-at-once and stepwise selection of cells with multiple genetic manipulations. Biochemical and biophysical research communications. 2021. 582. 93-99
  • Ari Hashimoto, Haruka Handa, Soichiro Hata, Akio Tsutaho, Takao Yoshida, Satoshi Hirano, Shigeru Hashimoto, Hisataka Sabe. Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer. Cell Communication and Signaling. 2021. 19. 1
  • Mei Horikawa, Hisataka Sabe, Yasuhito Onodera. Dual roles of AMAP1 in the transcriptional regulation and intracellular trafficking of carbonic anhydrase IX. Translational oncology. 2021. 15. 1. 101258-101258
  • Gyanu Parajuli, Murat Tekguc, James B Wing, Ari Hashimoto, Daisuke Okuzaki, Takeshi Hirata, Atsushi Sasaki, Takahide Itokazu, Haruka Handa, Hirokazu Sugino, et al. Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression. Cancer immunology research. 2021. 9. 8. 862-876
  • Hideo Nambu, Shingo Takada, Satoshi Maekawa, Junichi Matsumoto, Naoya Kakutani, Takaaki Furihata, Ryosuke Shirakawa, Takashi Katayama, Takayuki Nakajima, Katsuma Yamanashi, et al. Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance. Cardiovascular research. 2021. 117. 3. 805-819
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MISC (199)：
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Patents (12)：
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Books (29)：
  • 細胞骨格と接着
    共立出版 2006 ISBN:4320056426
  • 細胞骨格と接着
    共立出版 2006
  • Paxillin-associated ArfGAPs: their isoform specificities and roles in coordination.
    'Protein and Cell Regulation' vol.1. 'ARF family GTPases(ed. R. Kahn; Series editors: A. Ridney, J. Frampton; Kluwer Academic Publishers). 2003
  • 細胞-細胞,細胞-基質の相互作用
    岩波講座,現代医学の基礎2 "分子・細胞の生物学(]G0002[)"岩波書店 2000
  • 細胞接着を制御するシグナル
    医学&サイエンスミリーズ 羊土社 1999
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Lectures and oral presentations  (24)：
  • The Arf6 pathway: a major pathway driving the malignancy and drug-resistance of refractory cancers
    (2017)
  • The Arf6 pathway: a central pathway driving mesenchymal malignancies and drug-resistance of refractory cancers
    (2017)
  • Arf6 is a core driver of mesenchymal invasion and metastasis, and therapeutic resistance of different types of cancers under RTK and GPCR signaling
    (2016)
  • Different genome statuses in breast cancer and renal cancer generate the Arf6-based mesenchymal machinery critical for metastasis and poor survival
    (2014)
  • ゲノム・代謝変異と癌悪性度進展
    (社団法人がんと炎症・代謝研究会理事会 2014)
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Education (4)：
  • - 1986 Kyoto University
  • - 1986 Kyoto University Graduate School, Division of Medicine
  • - 1980 Kyoto University Faculty of Science
  • - 1980 Kyoto University Faculty of Science
Professional career (2)：
  • (BLANK)
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Work history (21)：
  • 2017/04 - 現在 慶応義塾大学医学部 客員教授(兼任)
  • 2010 - 現在 北海道大学 医学(系)研究科(研究院) 教授
  • 2000 - Osaka University Graduate School of Medicine
  • 2000 - Visiting Professor, Osaka Uinversity
  • 1999 - Kyoto University Graduate School of Biostudies
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Association Membership(s) (4)：
JAPAN SOCIETY FOR CELL BIOLOGY ,  日本生化学会 ,  日本癌学会 ,  日本分子生物学会
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