Rchr
J-GLOBAL ID：200901073734698534   Update date: May. 05, 2024

Okamoto Akimitsu

オカモト アキミツ | Okamoto Akimitsu
Affiliation and department：
The University of Tokyo Research Center for Advanced Science and Technology

About The University of Tokyo Research Center for Advanced Science and Technology


Job title： Initiative Research Scientist (Unit Leader)
Homepage URL  (2)： http://park.itc.u-tokyo.ac.jp/okamoto/index.html ,  http://www.riken.jp/lab-www/okamotoiru/index.htm
Research field  (10)： Genetics ,  Genomics ,  Space and planetary science ,  Bioorganic chemistry ,  Structural/physical organic chemistry ,  Synthetic organic chemistry ,  Green/sustainable/environmental chemistry ,  Biochemistry ,  Chemical biology ,  Molecular biochemistry
Research keywords  (13)： Dye design ,  Photodynamic Therapy ,  Origin of Life ,  Raman Spectroscopy ,  Cell Interaction ,  Epigenetics ,  Live Cell Imaging ,  In-Cell Organic Chemistry ,  Cell Immobilization ,  Chemical Protein Engineering ,  Nucleic Acid Chemistry ,  Organic Synthesis ,  Bioorganic Chemistry
Research theme for competitive and other funds  (40)：
  • 2023 - 2026 Unprecedented and potent immunoregulation provided by protein capture with functionalized small synthetic nucleic acids
  • 2023 - 2026 Studies on the development of antibody-drug conjugate orphan drugs based on photodynamic therapy targeting oral cancer.
  • 2022 - 2025 特定のヘテロクロマチン領域を認識し遺伝子発現を制御するメカニズムの解明
  • 2021 - 2023 Exploration of the modification of genomic higher-order structures in the cell nucleus by aggregation of chemically synthesized short nucleic acids
  • 2020 - 2023 PCI法を用いた蛍光標識抗体薬物複合体デリバリーによる次世代口腔癌治療法の開発
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Papers (197)：
  • Shinya Yamahira, Hidefumi Mitsuno, Misato Yamaoka, Teruyuki Nagamune, Akimitsu Okamoto, Ryohei Kanzaki, Satoshi Yamaguchi. Odorant-sensing cell micropatterns for odor discrimination. Biosensors and Bioelectronics: X. 2024. 18. 100473
  • Kunihiko Morihiro, Yasuhiro Tomida, Honami Ando, Akimitsu Okamoto. Copper-mediated siRNA activation for conditional control of gene expression. Bioorganic & Medicinal Chemistry Letters. 2024. 104. 129738-129738
  • Kunihiko Morihiro, Shunto Morita, Naoki Harada, Manami Baba, Jongmin Yum, Mitsuru Naito, Kanjiro Miyata, Genta Nagae, Akimitsu Okamoto. RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality. Journal of the American Chemical Society. 2024. 146. 2. 1346-1355
  • Masako Takatsu, Kunihiko Morihiro, Honoka Watanabe, Mizue Yuki, Takara Hattori, Kentaro Noi, Kohsuke Aikawa, Keiichi Noguchi, Masafumi Yohda, Takashi Okazoe, et al. Cellular Penetration and Intracellular Dynamics of Perfluorocarbon-Conjugated DNA/RNA as a Potential Means of Conditional Nucleic Acid Delivery. ACS Chemical Biology. 2023
  • Takafumi Furuhata, Phebee Angeline Devadasan Racheal, Iori Murayama, Usano Toyoda, Akimitsu Okamoto. One-Pot, Photocontrolled Enzymatic Assembly of the Structure-Defined Heterotypic Polyubiquitin Chain. Journal of the American Chemical Society. 2023
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MISC (47)：
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Patents (40)：
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Education (4)：
  • - 1998 Kyoto University
  • - 1998 Kyoto University Graduate School, Division of Engineering Department of Synthetic Chemistry and Biological Chemistry
  • - 1993 Kyoto University Faculty of Engineering
  • - 1993 Kyoto University Faculty of Engineering Synthetic Chemistry
Professional career (1)：
  • Doctor of Engineering (Kyoto University)
Work history (8)：
  • 2012/04 - 現在 The University of Tokyo RCAST Professor
  • 2012/01 - 2012/03 The University of Tokyo Department of Chemistry and Biotechnology Professor
  • 2011/04 - 2012/01 RIKEN Okamoto Nucleic Acid Chemistry Laboratory Associate Chief Scientist
  • 2006/04 - 2011/03 RIKEN Okamoto Initiative Research Unit Unit Leader
  • 1999 - 2006 京都大学工学研究科合成・生物化学専攻 助手
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Awards (8)：
  • 2014 - JSPS 10th JSPS Prize
  • 2008 - Royal Society of Chemistry, Organic & Biomolecular Chemistry Lecture Award
  • 2007 - 平成19年度科学技術分野の文部科学大臣表彰 若手科学者賞
  • 2005 - 日本化学会 進歩賞
  • 2005 - 光科学技術研究振興財団 研究表彰
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Association Membership(s) (11)：
KINKA CHEMICAL SOCIETY ,  日本光医学・光生物学会 ,  THE JAPANESE PHOTOCHEMISTRY ASSOCIATION ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  American Chemical Society ,  THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY ,  THE CHEMICAL SOCIETY OF JAPAN ,  The Japanese Peptide Society ,  Japan Society of Nucleic Acids Chemistry ,  The Japanese Society of Epigenetics ,  Royal Society of Chemistry
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