Komatsu Yasuo

コマツヤスオ | Komatsu Yasuo

Affiliation and department：
Other affiliations (1)：

Homepage URL (1)： https://unit.aist.go.jp/bpri/

Research field (3)： Pharmaceuticals - chemistry and drug development , Molecular biology , Biochemistry

Research keywords (8)： ribozyme , antisense , 核酸医薬 , oligonucleotide , microRNA , RNA , DNA , nucleic acid

Research theme for competitive and other funds (17)：

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Papers (107)：

Ahmed Mostafa Abdelhady, Yu Hirano, Kazumitsu Onizuka, Hidenori Okamura, Yasuo Komatsu, Fumi Nagatsugi. Synthesis of Crosslinked 2′-OMe RNA Duplexes Using 2-Amino-6-Vinylpurine and Their Application for Effective Inhibition of miRNA Function. Current Protocols. 2022. 2. 3. e386
Ruriko Fukushima, Tetsuya Suzuki, Yasuo Komatsu, Hiroyuki Kamiya. Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine. Mutation research. 2022. 825. 111794-111794
Yu Hirano, Yasuo Komatsu. Promotion of cytoplasmic localization of oligonucleotides by connecting cross-linked duplexes. RSC Advances. 2022. 12. 38. 24471-24477
Sho Okumura, Yu Hirano, Yasuo Komatsu. Stable duplex-linked antisense targeting miR-148a inhibits breast cancer cell proliferation. Scientific Reports. 2021. 11. 1. 11467-11467
Ahmed Mostafa Abdelhady, Yu Hirano, Kazumitsu Onizuka, Hidenori Okamura, Yasuo Komatsu, Fumi Nagatsugi. Synthesis of crosslinked 2′-OMe RNA duplexes and their application for effective inhibition of miRNA function. Bioorganic & Medicinal Chemistry Letters. 2021. 48. 128257-128257

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MISC (59)：

中村彰良, WANG Daole, 小松康雄, 小松康雄. Analysis of nucleotide addition in the 3’-5’ direction by human tRNAHis guanylyltransferase and its application to RNA 5’-modification. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
中村彰良, 汪道楽, 小松康雄. ヒト由来tRNA^His guanylsltransferaseの塩基認識機構およびRNA5’修飾への応用. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
中村彰良, WANG Daole, 小松康雄, 小松康雄. ヒト由来tRNA^His guanylyltransferaseによるミトコンドリアtRNA^Hisの5′末端修飾反応の解析. 日本RNA学会年会要旨集. 2019. 21st
中村彰良, 汪道楽, 小松康雄, 小松康雄. 3’-5’方向塩基付加反応におけるヒト由来Thg1の塩基認識機構. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
平野悠, 平野悠, 扇谷仁希, 千高佐知子, 三重安弘, 小松康雄, 小松康雄. クロスリンク2本鎖構造によるanti-miRNAオリゴの細胞内局在への影響. 日本核酸医薬学会年会講演要旨集. 2019. 5th

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Patents (19)：

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Books (4)：

Environmentally Responsive and Bright Fluorescent Probes Possessing Dansyl-modified Oligonucleotides under Hybridization of DNA and RNA.
Springer 2015 ISBN:9783319173054
Hydroxylamine, Oxime and Hydroxamic Acid Derivatives of Nucleic Acids.
WILEY 2010 ISBN:9780470682531
Regulation of ribozyme activity by oligonucleotides
Humana Press 2004 ISBN:9781592597468
Chemical RNA synthesis (Including RNA with unusual constituents).
Oxford 1999 ISBN:9780080431581

Professional career (1)：

Work history (12)：

2024/04 - 現在 National Institute of Advanced Industrial Science and Technology
2015/04 - 現在 Hokkaido University
2022/04 - 2024/03 National Institute of Advanced Industrial Science and Technology
2020/04 - 2022/03 National Institute of Advanced Industrial Science and Technology
2019/04 - 2020/03 National Institute of Advanced Industrial Science and Technology

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Awards (1)：

Association Membership(s) (4)：

RNA学会 , 日本核酸化学会 , 日本核酸医薬学会 , 日本薬学会

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