Art

J-GLOBAL ID：200902105760250005   Reference number：02A0182301

Biosynthesis of Hibarimicins. III. Structures of New Hibarimicin-related Metabolites Produced by Blocked Mutants.

ヒバリミシン類の生合成 III 遮断変異菌が生産するヒバリミシン関連性新代謝産物の構造

Author (9)： IGARASHI Y (Toyama Prefectural Univ., Toyama, JPN) ,  KAJIURA T (Toyama Prefectural Univ., Toyama, JPN) ,  FURUMAI T (Toyama Prefectural Univ., Toyama, JPN) ,  HORI H (Tamagawa Univ., Tokyo, JPN) ,  HIGASHI K (Tamagawa Univ., Tokyo, JPN) ,  ISHIYAMA T (Tamagawa Univ., Tokyo, JPN) ,  URAMOTO M (Tamagawa Univ., Tokyo, JPN) ,  UEHARA Y (National Inst. Infectious Diseases, Tokyo, JPN) ,  OKI T (Tamagawa Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 55  Issue： 1  Page： 61-70  Publication year： Jan. 25, 2002 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *enzyme inhibitor ,...
Semi thesaurus term： ヒバリミシンB ,...

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JST classification (1)： Antibiotic fermentation  (GX03000S)

Substance index (9)： Hibarimicin B ,  (6R,6aR,6a′R,7S,7′S,8R,8′R,9S,9′S,10S,10′S,10aS,10a′S)-6,6′,6a,6a′,7,7′,8,8′,9,9′,10,10′-Dodecahydro-1,1′,5,8,8′,10′,10a,10a′,12,12′-decahydroxy-7,7′-bis(2,6-dideoxy-α-D-ribo-hexopyranosyloxy)-9,9′-bis[4-O-(4-C-acetyl-2,3,6-trideoxy-α-L-threo-hexopyranosyl)-2,3,6-trideoxy-β-L-erythro-hexopyranosyloxy]-3,3′,4,4′-tetramethoxy-10,10′-dipropyl-6,10-epoxy-2,2′-binaphthacene-11,11′(10aH,10a′H)-dione ,  (6R,6aR,6a′R,7S,7′S,8R,8′R,9S,9′S,10S,10′S,10aS,10a′S)-6,6′,6a,6a′,7,7′,8,8′,9,9′,10,10′-Dodecahydro-5,7,7′,8,8′,9,9′,10′,10a,10a′,12,12′-dodecahydroxy-3′,4′-dimethoxy-10,10′-dipropyl-1′,3:6,10-diepoxy-2,2′-binaphthacene-1,4,11,11′(10aH,10a′H)-tetrone ,  Hibarimicinone ,  (6R,6aR,6a′R,7S,7′S,8R,8′R,9S,9′S,10S,10′S,10aS,10a′S)-6,6′,6a,6a′,7,7′,8,8′,9,9′,10,10′-Dodecahydro-5,8,8′,10′,10a,10a′,12,12′-octahydroxy-7,7′-bis(2,6-dideoxy-α-D-ribo-hexopyranosyloxy)-9,9′-bis(5-hydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-3′,4′-dimethoxy-10,10′-dipropyl-1′,3:6,10-diepoxy-2,2′-binaphthacene-1,4,11,11′(10aH,10a′H)-tetrone ,  HMP-M1 ,  1,8-Dihydroxy-2-(1-oxo-3-hydroxy-2-hexenyl)-3-methyl-9,10-anthraquinone ,  HMP-M3 ,  2,2′,4,4′-Tetrahydroxy-6-propyl-6′-(2-oxo-4-hydroxy-2H-pyran-6-yl)benzophenone

Reference (3)：

• 1) KAJIURA, T.; T. FURUMAI, Y. IGARASHI, H. HORI, K. HIGASHI, T. ISHIYAMA, M. URAMOTO, Y. UEHARA & T. OKI: Biosynthesis of hibarimicins. II. Elucidation of biosynthetic pathway by cosynthesis using blocked mutants. J. Antibiotics 55: 53-60, 2002
• 2) NISHIMURA, H.; T. KIMURA, K. TAWARA, K. SASAKI, K. NAKAJIMA, N. SHIMAOKA, S. OKAMOTO, M. SHIMOHIRA & J. ISONO: Aburamycin, a new antibiotic. J. Antibiotics, Ser. A 10: 205-212, 1957
• 3) HORI, H.; Y. IGARASHI, T. KAJIURA, T. FURUMAI, K. HIGASHI, T. ISHIYAMA, M. URAMOTO, Y. UEHARA & T. OKI: Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora. II. Structural study. J. Antibiotics 51: 402-417, 1998

Terms in the title (7)： ミシン ,  生合成 ,  遮断 ,  変異 ,  菌 ,  関連性 ,  代謝産物