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J-GLOBAL ID：200902144099963542   Reference number：02A0182300

Biosynthesis of Hibarimicins. II. Elucidation of Biosynthetic Pathway by Cosynthesis Using Blocked Mutants.

ヒバリミシン類の生合成 II 遮断変異菌を用いた共同合成による生合成経路の解析

Author (9)： KAJIURA T (Toyama Prefectural Univ., Toyama, JPN) ,  FURUMAI T (Toyama Prefectural Univ., Toyama, JPN) ,  IGARASHI Y (Toyama Prefectural Univ., Toyama, JPN) ,  HORI H (Tamagawa Univ., Tokyo, JPN) ,  HIGASHI K (Tamagawa Univ., Tokyo, JPN) ,  ISHIYAMA T (Tamagawa Univ., Tokyo, JPN) ,  URAMOTO M (Tamagawa Univ., Tokyo, JPN) ,  UEHARA Y (National Inst. Infectious Diseases, Tokyo, JPN) ,  OKI T (Tamagawa Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 55  Issue： 1  Page： 53-60  Publication year： Jan. 25, 2002 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *enzyme inhibitor ,...
Semi thesaurus term： ヒバリミシンB ,...

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JST classification (1)： Antibiotic fermentation  (GX03000S)

Substance index (6)： Hibarimicin B ,  Hibarimicinone ,  (6R,6aR,6a′R,7S,7′S,8R,8′R,9S,9′S,10S,10′S,10aS,10a′S)-6,6′,6a,6a′,7,7′,8,8′,9,9′,10,10′-Dodecahydro-1,1′,5,8,8′,10′,10a,10a′,12,12′-decahydroxy-7,7′-bis(2,6-dideoxy-α-D-ribo-hexopyranosyloxy)-9,9′-bis[4-O-(4-C-acetyl-2,3,6-trideoxy-α-L-threo-hexopyranosyl)-2,3,6-trideoxy-β-L-erythro-hexopyranosyloxy]-3,3′,4,4′-tetramethoxy-10,10′-dipropyl-6,10-epoxy-2,2′-binaphthacene-11,11′(10aH,10a′H)-dione ,  (6aR,6a′R,7S,7′S,8R,8′R,9S,9′S,10S,10′S,10aS,10a′S)-6,6′,6a,6a′,7,7′,8,8′,9,9′,10,10′-Dodecahydro-1,1′,7,7′,8,8′,9,9′,10,10′,10a,10a′,12,12′-tetradecahydroxy-3,3′,4,4′-tetramethoxy-10,10′-dipropyl-2,2′-binaphthacene-11,11′(10aH,10a′H)-dione ,  (6R,6aR,6a′R,7S,7′S,8R,8′R,9S,9′S,10S,10′S,10aS,10a′S)-6,6′,6a,6a′,7,7′,8,8′,9,9′,10,10′-Dodecahydro-5,7,7′,8,8′,9,9′,10′,10a,10a′,12,12′-dodecahydroxy-3′,4′-dimethoxy-10,10′-dipropyl-1′,3:6,10-diepoxy-2,2′-binaphthacene-1,4,11,11′(10aH,10a′H)-tetrone ,  (6R,6aR,6a′R,7S,7′S,8R,8′R,9S,9′S,10S,10′S,10aS,10a′S)-6,6′,6a,6a′,7,7′,8,8′,9,9′,10,10′-Dodecahydro-5,8,8′,10′,10a,10a′,12,12′-octahydroxy-7,7′-bis(2,6-dideoxy-α-D-ribo-hexopyranosyloxy)-9,9′-bis(5-hydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-3′,4′-dimethoxy-10,10′-dipropyl-1′,3:6,10-diepoxy-2,2′-binaphthacene-1,4,11,11′(10aH,10a′H)-tetrone

Reference (5)：

• 1) KAJIURA, T.; H. HORI, Y IGARASHI, T. FURUMAI, K. HIGASHI, T. ISHIYAMA, M. URAMOTO, Y. UEHARA & T. OKI: Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora. I. Taxonomy, fermentation, isolation and biological properties. J. Antibiotics 51: 394-401, 1998
• 2) HORI, H.; Y. IGARASHI, T. KAJIURA, T. FURUMAI, K. HIGASHI, T. ISHIYAMA, M. URAMOTO, Y. UEHARA & T. OKI: Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora. II. Structural studied. J. Antibiotics 51: 402-417, 1998
• 3) HORI, H.; Y. IGARASHI, T. KAJIURA, T. FURUMAI, K. HIGASHI, T. ISHIYAMA, M. URAMOTO, Y. UEHARA & T. OKI: Biosynthesis of hibarimicins. I. ¹³C-labeling experiments. J. Antibiotics 55: 46-52, 2002
• 4) IGARASHI, Y.; T. KAJIURA, H. HORI, T. FURUMAI, K. HIGASHI, T. ISHIYAMA, M. URAMOTO, Y. UEHARA & T. OKI: Biosynthesis of hibarimicins. III. Structures of new hibarimicin-related metabolites produced by blocked mutants. J. Antibiotics 55: 61-70, 2002
• 5) KAKINUMA, S.; K. SUZUKI, M. HATORI, K. SAITOH, T. HASEGAWA, T. FURUMAI & T. OKI: Biosynthesis of the pradimicin family antibiotics. III. Biosynthetic pathway of both pradimicins and benanomicins. J. Antibiotics 46: 430-440, 1993

Terms in the title (8)： ミシン ,  生合成 ,  遮断 ,  変異 ,  菌 ,  共同 ,  生合成経路 ,  解析