Art

J-GLOBAL ID：200902110254012744   Reference number：01A1010682

A Simple Screening System for Anti-HIV Drugs: Syncytium Formation Assay Using T-Cell Line Tropic and Macrophage Tropic HIV env Expressing Cell Lines. Establishment and Validation.

抗HIV薬の簡易スクリーニング系 HIV envを発現したT細胞向性およびマクロファージ向性細胞系を用いたシンシチウム形成アッセイ 確立と確認

Author (7)： CHIBA H (Kitasato Univ., Tokyo, JPN) ,  ASANUMA S (Kitasato Univ., Tokyo, JPN) ,  OKAMOTO M (Kitasato Univ., Tokyo, JPN) ,  INOKOSHI J (Kitasato Univ., Tokyo, JPN) ,  TANAKA H (Kitasato Univ., Tokyo, JPN) ,  FUJITA K (Showa Univ., Tokyo, JPN) ,  OMURA S (Kitasato Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 54  Issue： 10  Page： 818-826  Publication year： Oct. 25, 2001 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *anti-AIDS agent ,...
Semi thesaurus term： T lymphocyte ,...

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JST classification (2)： Basic research of antiviral drugs  (GW17040O) ,  Bioassay  (EA03060N)

Substance index (6)： Benanomicin A ,  Blasticidin S ,  Gentamicin G-418 ,  T-134 ,  T140 ,  TAK-779

Reference (30)：

• 1) HOGG, R. S.; S. A. RHONE, B. YIP, C. SHERLOCK, B. CONWAY, M. T. SCHECHTER, M. V O'SHAUGHNESSY & J. S. MONTANER: Antiviral effect of double and triple drug combinations amongst HIV-infected adults: lessons from the implementation of viral load-driven antiretroviral therapy. AIDS 12: 279-284, 1998
• 2) D'SouzA, M. P.; J. S. CAIRNS & S. F. PLAEGER: Current evidence and future directions for targeting HIV entry: therapeutic and prophylactic strategies. JAMA 284: 215-222,2000
• 3) OMURA, S.; H. TANAKA, K. MATSUZAKI, H. IKEDA & R. MASUMA:. Isochromophilones I and II, novel inhibitors against gp120-CD4 binding from Penicillium sp. J. Antibiotics 46: 1908-1911, 1993
• 4) MATSUZAKI, K.; H. IKEDA, R. MASUMA, H. TANAKA & S. OMURA: Isochromophilones I and II, novel inhibitors against gp!20-CD4 binding produced by Penicillium multicolor FO-2338. I. Screening, taxonomy, fermentation, isolation and biological activity. J. Antibiotics 48: 703-707, 1995
• 5) MATSUZAKI, K.; H. TANAKA & S. OMURA: Isochromophilones I and II, novel inhibitors against gp120-CD4 binding produced by Penicillium multicolor FO-2338. II. Structure elucidation. J. Antibiotics 48: 708-713, 1995

Terms in the title (9)： 抗HIV薬 ,  簡易スクリーニング ,  HIV ,  発現 ,  マクロファージ ,  向性 ,  細胞系 ,  シンシチウム ,  アッセイ