Art

J-GLOBAL ID：200902115304414417   Reference number：00A0854178

Molecular Cloning and Overexpression of the Gene Encoding an NADPH-Dependent Carbonyl Reductase from Candida magnoliae, Involved in Stereoselective Reduction of Ethyl 4-Chloro-3-oxobutanoate.

Candida magnoliae由来のNADPH依存性4-クロロ-3-オキソ酪酸エチル還元酵素の遺伝子クローニング

Author (6)： YASOHARA Y (Kaneka Corp., Takasago, JPN) ,  KIZAKI N (Kaneka Corp., Takasago, JPN) ,  HASEGAWA J (Kaneka Corp., Takasago, JPN) ,  WADA M (Kyoto Univ., Kyoto, JPN) ,  KATAOKA M (Kyoto Univ., Kyoto, JPN) ,  SHIMIZU S (Kyoto Univ., Kyoto, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 64  Issue： 7  Page： 1430-1436  Publication year： Jul. 23, 2000 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *carbonyl oxidoreductase ,...
Semi thesaurus term： Candida

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JST classification (2)： Structure and chemistry of genes  (EC02020U) ,  Enzyme in general  (EB09010D)

Substance index (2)： 4-Chloroacetoacetic acid ethyl ,  2-(6)-1307

Reference (24)：

• 1) Karanewsky, D. S., Badia, M. C., Ciosek, C. P., Jr., Robl, J. F., Sofia, M. J., Simpkins, L. M., DeLange, B., Harrity, T. W., Biller, S. A., and Gorden, E. M., Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[2-(arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis. J. Med. Chem., 33, 2925-2956 (1990).
• 2) Zhou, B., Gopalan, A. S., VanMiddlesworth, F., Shieh, W.-R., and Sih, C. J., Stereochemical control of yeast reductions. 1. asymmetric synthesis of L-carnitine. J. Am. Chem. Soc., 105, 5925-5926 (1983).
• 3) Yasohara, Y., Kizaki, N., Hasegawa, J., Takahashi, S., Wada, M., Kataoka, M., and Shimizu, S., Synthesis of optically active ethyl 4-chloro-3-hydroxybutanoate by microbial reduction. Appl. Microbiol. Biotechnol., 51, 847-851 (1999).
• 4) Wada, M., Kataoka, M., Kawabata, H., Yasohara, Y., Kizaki, N., Hasegawa, J., and Shimizu, S., Purification and characterization of NADPH-dependent carbonyl reductase, involved in stereoselective reduction of ethyl 4-chloro-3-oxobutanoate, from Candida magnoliae. Biosci.Biotechnol. Biochem., 62, 280-285 (1998).
• 5) Wada, M., Kawabata, H., Yoshizumi, A., Kataoka, M., Nakamori, S., Yasohara, Y., Kizaki, N., Hasegawa, J., and Shimizu, S., Occurrence of multiple ethyl 4-chloro-3-oxobutanoate-reducing enzymes in Candida magnoliae. J. Biosci. Bioeng., 87, 144-148 (1998).

Terms in the title (6)： Candida ,  NADPH ,  依存性 ,  4-クロロ-3-オキソ酪酸エチル ,  還元酵素 ,  遺伝子クローニング