Art

J-GLOBAL ID：200902126841647870   Reference number：02A0782750

In Vitro and In Vivo Antimalarial Activities of the Monoglycoside Polyether Antibiotic, K-41 against Drug Resistant Strains of Plasmodia.

マラリア原虫の薬物耐性菌株に対するモノグリコシドポリエーテル抗生物質,K-41のin vitroおよびin vivo抗マラリア活性

Author (9)： OTOGURO K (Kitasato Inst., JPN) ,  ISHIYAMA A (Kitasato Inst., JPN) ,  UI H (Kitasato Univ., Tokyo, JPN) ,  KOBAYASHI M (Kitasato Inst., JPN) ,  MANABE C (Kitasato Inst., JPN) ,  YAN G (Chinese Acad. Medical Sci., Beijing, JPN) ,  TAKAHASHI Y (Kitasato Univ., Tokyo, JPN) ,  TANAKA H (Kitasato Univ., Tokyo, JPN) ,  OMURA S (Kitasato Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 55  Issue： 9  Page： 832-834  Publication year： Sep. 25, 2002 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Plasmodium ,...
Semi thesaurus term： bridged compound ,...

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JST classification (2)： Basic research of antibiotics acting on pathogenic organisms  (GX05020C) ,  Basic research of antiprotozoan drugs and anthelmintics  (GW17080G)

Substance index (6)： Artemether ,  Artesunate ,  Artemisin ,  Chloroquine ,  Pyrimethamin ,  K-41A

Reference (7)：

• 1) OTOGURO, K.; A. KOHANA, C. MANABE, A. ISHIYAMA, H. UI, K. SIOMI, H. YAMADA & S. OMURA: Potent antimalarial activities of polyether antibiotic, X-206. J. Antibiotics 54: 658-663, 2001
• 2) TSUJI, N.; K. NAGASHIMA, M. KOBAYASHI, Y. WAKISAKA, Y. KAWAMURA, S. KOZUKI & M. MAYAMA: Two new antibiotics, A-218 and K-41 isolation and characterization. J. Antibiotics 29: 10-14, 1976
• 3) PETERS, W.; J. H. PORTUS & B. L. ROBINSON: The chemotherapy of rodent malaria. XXII. The value of drug-resistant strains of P. berghei in screening for blood schizonticidal activity. Ann. Trop. Med. Parasitol. 69: 155-171, 1975
• 4) BÉRDY, J.: Polyether antibiotics. In CRC Handbook of Antibiotic Compounds. Volume V. pp. 461-465, CRC Press, Inc. Boca Raton, Florida, 1981
• 5) RAETHER, W.; H. SEIDENATH, H. MEHLHORN & H. J. GANSTER: The action of salinomycin-Na and lasalocid-Na on chloroquine- and mepacrine-resistant line of Plasmodium berghei K 173-strain in Wistar rats, Z. Parasitenkd. 71: 567-574, 1985

Terms in the title (5)： マラリア原虫 ,  薬物耐性 ,  菌株 ,  抗生物質 ,  抗マラリア活性