Art

J-GLOBAL ID：200902133927327203   Reference number：02A0337248

Serum HCV RNA levels during early phase of recombinant interferon alfa-2a(Roferon A) therapy for chronic hepatitis C and efficacy of short-term therapy with earlier loss of viremia.

慢性C型肝炎患者の組み換えインターフェロンα2a(ロフェロンA)治療中の初期での血清HCV RNA量とウイルス血症の初期消失を示す短期間治療の効果

Author (9)： KAKUMU S (Aichi Medical Univ. School of Medicine, Aichi, JPN) ,  MATSUSHIMA T (Hakodate Municipal Hospital, Hakodate, JPN) ,  SATO S (Iwate Medical Univ., Morioka, JPN) ,  KOBAYASHI K (Kanazawa Univ. School of Medicine, Kanazawa, JPN) ,  KIYOSAWA K (Shinshu Univ. School of Medicine, Matsumoto, JPN) ,  HAYASHI N (Osaka Univ. Graduate School of Medicine, Suita, JPN) ,  TSUJI T (Okayama Univ. School of Medicine, Okayama, JPN) ,  SATA M (Kurume Univ., Kurume, JPN) ,  ORIGASA H (Toyama Medical and Pharmaceutical Univ., Toyama, JPN)
Material： Hepatology Research  (Hepatol Res)
Volume： 22  Issue： 2  Page： 152-160  Publication year： Feb. 2002 
JST Material Number： W1284A  ISSN： 1386-6346  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： GPT ,...

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JST classification (2)： Clinical application of antiviral drugs  (GW17050Z) ,  Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G)

Reference (21)：

• NEUMANN, AU. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science. 1998, 282, 103-107
• BUTI, M. Quantification of serum hepatitis C virus RNA with daily or standard interferon doses plus ribavirin in nonresponder potients with chronic hepatitis C. Dig Dis Sci. 2000, 45, 685-689
• BEKKERING, FC. Ultrarapid hepatitis C Virus clearance by daily high-dose interferon in non-responders to standard therapy. J Hepatol. 1998, 28, 960-964
• MAGALINI, A. Decrease of HCV RNA after three days of daily interferon treatment is predictive of the virological response at one month. J Clin Lab Anal. 2000, 14, 120-124
• PERELSON, AS. Viral kinetics and mathematical models. Am J Med. 1999, 107, 49S-52S

Terms in the title (11)： 慢性C型肝炎 ,  患者 ,  組み換え ,  インターフェロンα2a ,  治療 ,  初期 ,  血清 ,  HCV ,  RNA ,  ウイルス血症 ,  短期間