Art

J-GLOBAL ID：200902134154481166   Reference number：00A1004278

Reversal of Multidrug Resistance by 7-O-Benzoylpyripyropene A in Multidrug-Resistant Tumor Cells.

多剤耐性腫よう細胞において,7-O-ベンゾイルピリピロペンAによる多剤耐性の反転現象

Author (8)： RHO M-C (Kitasato Univ., Tokyo, JPN) ,  HAYASHI M (Kitasato Univ., Tokyo, JPN) ,  FUKAMI A (Kitasato Univ., Tokyo, JPN) ,  OBATA R (Kitasato Univ., Tokyo, JPN) ,  SUNAZUKA T (Kitasato Univ., Tokyo, JPN) ,  TOMODA H (Kitasato Univ., Tokyo, JPN) ,  KOMIYAMA K (Kitasato Univ., Tokyo, JPN) ,  OMURA S (Kitasato Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 53  Issue： 10  Page： 1201-1206  Publication year： Oct. 25, 2000 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： P glycoprotein ,...
Semi thesaurus term： bridged compound

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JST classification (1)： Basic research of antitumor(=antineoplastic)antibiotics  (GX05040Y)

Substance index (3)： Vincristine ,  Azidopine ,  7-O-Benzoylpyripyropene A

Reference (29)：

• 1) Loo, T. W. & D. M. CLARKE: Merck Frosst Award Lecture 1998. Molecular dissection of the human multidrug resistance P-glycoprotein. Biochem. Cell Biol. 77: 11-23, 1999
• 2) AMBUDKAR, S. V; S. DEY, C. A. HRYCYNA, M. RAMACHANDRA, I. PASTAN & M. M. GOTTESMAN: Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu. Rev. Pharmacol. Toxicol. 39: 361-398, 1999
• 3) NAITO, M. & T. TSURUO: Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement. Cancer Res. 49: 1452-1455, 1989
• 4) ENDICOTT, J. A. & V LING: The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem. 58: 137-171, 1989
• 5) URBATSCH, I. L. & A. E. SENIOR: Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein. Arch. Biochem. Biophys. 316: 135-140, 1995

Terms in the title (4)： 多剤耐性 ,  腫よう細胞 ,  反転 ,  現象