Art

J-GLOBAL ID：200902168017791214   Reference number：02A0123979

Tyropeptins A and B, New Proteasome Inhibitors Produced by Kitasatospora sp. MK993-dF2. II. Structure Determination and Synthesis.

チロペプチンAとB,Kitasatospora sp.MK993-dF2が生産する物質で,プロテアソームの新抑制剤 II 構造決定と合成

Author (7)： MOMOSE I (Inst. Microbial Chemistry, Tokyo, JPN) ,  SEKIZAWA R (Inst. Microbial Chemistry, Tokyo, JPN) ,  HIROSAWA S (Inst. Microbial Chemistry, Tokyo, JPN) ,  IKEDA D (Inst. Microbial Chemistry, Tokyo, JPN) ,  NAGANAWA H (Inst. Microbial Chemistry, Tokyo, JPN) ,  IINUMA H (Inst. Microbial Chemistry, Tokyo, JPN) ,  TAKEUCHI T (Inst. Microbial Chemistry, Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 54  Issue： 12  Page： 1004-1012  Publication year： Dec. 25, 2001 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antineoplastic antibiotics ,...
Semi thesaurus term： Kitasatospora sp. MK993-dF2

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JST classification (2)： Antibiotic-producing microorganisms  (GX02000L) ,  Analysis of drugs  (GV01040Q)

Substance index (6)： Tyropeptin A ,  Tyropeptin B ,  (S)-2-[(N-Isovaleryl-L-Tyr-L-Val-)amino]-3-(4-hydroxyphenyl)-1-propanol ,  (R)-2-[(N-Isovaleryl-L-Tyr-L-Val-)amino]-3-(4-hydroxyphenyl)-1-propanol ,  (S)-2-[(N-Butyryl-L-Tyr-L-Leu-)amino]-3-(4-hydroxyphenyl)-1-propanol ,  (R)-2-[(N-Butyryl-L-Tyr-L-Leu-)amino]-3-(4-hydroxyphenyl)-1-propanol

Reference (8)：

• 1) HERSHKO, A. & A. CIECHANOVER: The ubiquitin system for protein degradation. Annu. Rev. Biochem. 61: 761 - 807, 1992
• 2) MOMOSE, L; R. SEKIZAWA, H. HASHIZUME, N. KINOSHITA, M. HAMADA, H. IINUMA & T. TAKEUCHI: Tyropeptins A and B, new proteasome inhibitors produced by Kitasatospora sp. MK993-dF2. I. Taxonomy, isolation, physico-chemical properties and biological activities. J. Antibiotics 54: 997-1003, 2001
• 3) TSUBUKI, S.; H. KAWASAKI, Y. SAITO, N. MIYASHITA, M. INOMATA & S. KAWASHIMA: Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome. Biochem. Biophys. Res. Commun. 196: 1195-1201, 1993
• 4) ADAMS, I; M. BEHNKE, S. CHEN, A. A. CRUICKSHANK, L. R. DICK, L. GRENIER, J. M. KLUNDER, Y. M. L. PLAMONDON & R. L. STEIN: Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids. Bioorg. Med. Chem. Lett. 8: 333-338, 1998
• 5) OMURA, S.; T. FUJIMOTO, K. OTOGURO, K. MATSUZAKI, R. MORIGUCHI, H. TANAKA & Y. SASAKI: Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J. Antibiotics 44: 113 - 116, 1991

Terms in the title (4)： Kitasatospora ,  物質 ,  プロテアソーム ,  抑制剤