Art

J-GLOBAL ID：200902180557415351   Reference number：02A0317569

Effects of Hibarimicins and Hibarimicin-Related Compounds Produced by Microbispora on v-Src Kinase Activity and Growth and Differentiation of Human Myeloid Leukemia HL-60 Cells.

v-Srcキナーゼ活性とヒト骨髄白血病HL60細胞の分化に与えるMicrobiosporaにより生産されるヒバリミシンとヒバリミシン関連物質の影響

Author (9)： CHO S I (National Inst. Infectious Diseases, Tokyo, JPN) ,  FUKAZAWA H (National Inst. Infectious Diseases, Tokyo, JPN) ,  HONMA Y (Saitama Cancer Center Res. Inst., Saitama, JPN) ,  KAJIURA T (Toyama Prefectural Univ., Toyama, JPN) ,  HORI H (Tamagawa Univ., Tokyo, JPN) ,  IGARASHI Y (Toyama Prefectural Univ., Toyama, JPN) ,  FURUMAI T (Toyama Prefectural Univ., Toyama, JPN) ,  OKI T (Toyama Prefectural Univ., Toyama, JPN) ,  UEHARA Y (National Inst. Infectious Diseases, Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 55  Issue： 3  Page： 270-278  Publication year： Mar. 25, 2002 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *enzyme inhibitor ,...
Semi thesaurus term： ヒバリミシン ,...

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JST classification (1)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (17)： Hibarimicin A ,  Hibarimicin B ,  Hibarimicin C ,  Hibarimicin D ,  Hibarimicin E ,  Hibarimicin G ,  Hibarimicin H ,  Hibarimicin I ,  Hibarimicinone ,  (6R,6aR,6a′R,7S,7′S,8R,8′R,9S,9′S,10S,10′S,10aS,10a′S)-6,6′,6a,6a′,7,7′,8,8′,9,9′,10,10′-Dodecahydro-5,7,7′,8,8′,9,9′,10′,10a,10a′,12,12′-dodecahydroxy-3′,4′-dimethoxy-10,10′-dipropyl-1′,3:6,10-diepoxy-2,2′-binaphthacene-1,4,11,11′(10aH,10a′H)-tetrone ,  (6R,6aR,6a′R,7S,7′S,8R,8′R,9S,9′S,10S,10′S,10aS,10a′S)-6,6′,6a,6a′,7,7′,8,8′,9,9′,10,10′-Dodecahydro-5,8,8′,10′,10a,10a′,12,12′-octahydroxy-3′,4′-dimethoxy-7,7′-bis[(2,6-dideoxy-α-L-ribo-hexopyranosyl)oxy]-9,9′-bis[(2,3,6-trideoxy-β-D-erythro-hexopyranosyl)oxy]-10,10′-dipropyl-1′,3:6,10-diepoxy-2,2′-binaphthacene-1,4,11,11′(10aH,10a′H)-tetrone ,  (6aR,6a′R,7S,7′S,8R,8′R,9S,9′S,10S,10′S,10aS,10a′S)-6,6′,6a,6a′,7,7′,8,8′,9,9′,10,10′-Dodecahydro-1,1′,5,7,7′,8,8′,9,9′,10,10′,10a,10a′,12,12′-pentadecahydroxy-3,3′,4,4′-tetramethoxy-10,10′-dipropyl-2,2′-binaphthacene-11,11′(10aH,10a′H)-dione ,  (6aR,6a′R,7S,7′S,8R,8′R,9S,9′S,10S,10′S,10aS,10a′S)-6,6′,6a,6a′,7,7′,8,8′,9,9′,10,10′-Dodecahydro-1,1′,5,7,7′,8,8′,9,9′,10,10′,10a,10a′,12,12′-pentadecahydroxy-3,3′,4,4′-tetramethoxy-7,7′-bis[(2,6-dideoxy-α-L-ribo-hexopyranosyl)oxy]-9,9′-bis[[4-O-(2,3,6-trideoxy-4-C-acetoxy-α-L-threo-hexopyranosyl)-2,3,6-trideoxy-β-D-erythro-hexopyranosyl]oxy]-10,10′-dipropyl-2,2′-binaphthacene-11,11′(10aH,10a′H)-dione ,  HMP-M1 ,  1,8-Dihydroxy-2-(1-oxo-3-hydroxy-2-hexenyl)-3-methyl-9,10-anthraquinone ,  2-Propyl-4-oxo-8-(2,6-dihydroxybenzoyl)-4H-1-benzopyran-5,7-dicarboxylic acid ,  4-Hydroxy-6-[2-(2-propyl-4,6-dihydroxybenzoyl)-3,5-dihydroxybenzyl]-2H-pyran-2-one

Reference (10)：

• 1) HUNTER, T. & J. A. COOPER: Protein tyrosine kinases. Ann. Rev. Biochem. 54: 897-930, 1985
• 2) COLLINS, S. J.: The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood. 70: 1233-1244, 1987
• 3) COLLINS, S. J.; A. BODNER, R. TING & R. C. GALLO: Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL-60) by compounds which induce differentiation of murine leukemia cells. Int. J. Cancer. 25: 213-218, 1980
• 4) KAJIURA, T.; T. FURAMAI, Y. IGARASHI, H. HORI, K. HIGASHI, T. ISHIYAMA, M. URAMOTO, Y. UEHARA & T. OKI: Signal transduction inhibitors, Hibarimicins A, B, C, D and G produced by Microbispora. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties. J. Antibiotics 51: 394-401, 1998
• 5) HORI, H.; Y. IGARASHI, T. KAJIURA, T. FURAMAI, K. HIGASHI, T. ISHIYAMA, M. URAMOTO, Y. UEHARA & T. OKI: Signal transduction inhibitors, hibarimicins A, B, C, D, and G produced by Microbispora. II. Structural studies. J. Antibiotics 51: 402-417, 1998

Terms in the title (10)： v-Src ,  キナーゼ ,  活性 ,  ヒト ,  骨髄 ,  白血病 ,  HL60細胞 ,  分化 ,  ミシン ,  物質