Art

J-GLOBAL ID：200902199886334543   Reference number：01A0016916

Studies on the Drugs against Refractory Diseases. Part 2. Anti-cancer Activities of Pyrazolo[1,5-a]indole Derivatives.

難治性疾患に対する薬剤 2 ピラゾロ[1,5-a]インドール誘導体の抗癌活性

Author (4)： KATAYAMA H (Niigata Coll. Pharmacy, Niigata, JPN) ,  KIRYU Y (Niigata Coll. Pharmacy, Niigata, JPN) ,  KANEKO K (Niigata Coll. Pharmacy, Niigata, JPN) ,  OHSHIMA R (Niigata Coll. Pharmacy, Niigata, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 48  Issue： 11  Page： 1628-1633  Publication year： Nov. 01, 2000 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antitumor action ,...

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JST classification (2)： Pyrazoles  (CF07082G) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (18)： 1-Methyl-2-phenyl-4-benzylidene-4H-pyrazolo[1,5-a]indol-1-ium ,  1-Methyl-2-phenyl-4-[4-(dimethylamino)benzylidene]-4H-pyrazolo[1,5-a]indol-1-ium ,  1-Methyl-2-phenyl-4-(4-nitrobenzylidene)-4H-pyrazolo[1,5-a]indol-1-ium ,  N,N-Dimethyl-4-(2-phenyl-4H-pyrazolo[1,5-a]indole-4-ylidenemethyl)aniline ,  4-(2-Phenyl-4H-pyrazolo[1,5-a]indole-4-ylidenemethyl)phenyltrimethylaminium ,  1-Methyl-2-styryl-4-[4-(dimethylamino)benzylidene]-4H-pyrazolo[1,5-a]indole-1-ium ,  1-Methyl-2-(4-chlorophenyl)-4-[4-(dimethylamino)benzylidene]-4H-pyrazolo[1,5-a]indole-1-ium ,  1-Methyl-2-phenyl-4-[4-(dimethylamino)cinnamylidene]-4H-pyrazolo[1,5-a]indole-1-ium ,  1-Methyl-2-phenyl-4-[3,4,5-trimethoxybenzylidene]-4H-pyrazolo[1,5-a]indole-1-ium ,  1-Methyl-2-(1-adamantyl)-4-[4-(dimethylamino)benzylidene]-4H-pyrazolo[1,5-a]indole-1-ium ,  1,2-Dimethyl-4-[4-(dimethylamino)benzylidene]-4H-pyrazolo[1,5-a]indole-1-ium ,  1-Methyl-2-(ethoxycarbonyl)-4-[4-(dimethylamino)benzylidene]-4H-pyrazolo[1,5-a]indole-1-ium ,  1-Methyl-2-phenyl-4-[2-methoxy-4-(dimethylamino)benzylidene]-4H-pyrazolo[1,5-a]indole-1-ium ,  2-Allylphenylhydrazine ,  2-(Hydroxymethyl)indoline-1-amine ,  2-Phenyl-4H-pyrazolo[1,5-a]indole ,  4-(Dimethylamino)benzaldehyde ,  4-[α-Hydroxy-4-(dimethylamino)benzylidene]-2-phenyl-4H-pyrazolo[1,5-a]indole

Reference (13)：

• 1) Katayama H., Kawada Y., Kaneko K., Oshiyama T., Takatsu N., Chem. Pharm. Bull., 47, 48-53 (1999).
• 2) Katayama H., Kawada Y., Kaneko K., Oshiyama T., Takatsu N., Chem. Pharm. Bull., 47, 48-53 (1999).
• 3) Katayama H., Takatsu N., Kitano H., Shimaya Y., Chem. Pharm. Bull., 38, 1129-1135 (1990).
• 4) Shen J.-K., Katayama H., J. Chem. Soc. Perkin Trans. 1, 1994, 1871-1877.
• 5) Shen J.-K., Katayama H., Takatsu N., Shiro I., J. Chem. Soc. Perkin Trans. 1, 1993, 2087-2097.

Terms in the title (4)： 難治性疾患 ,  薬剤 ,  インドール誘導体 ,  抗癌活性