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J-GLOBAL ID：200902202701066387   Reference number：06A0305573

Fasting-induced reduction in locomotor activity and reduced response of orexin neurons in carnitine-deficient mice

カルニチン欠乏マウスにおける絶食誘発性自発運動低下およびオレキシンニューロンの反応低下

Author (20)： YOSHIDA Goichiro (Dep. of Molecular Metabolism and Biochemical Genetics, Kagoshima Univ. Graduate School of Medical and Dental ...) ,  YOSHIDA Goichiro (Dep. of Health Sci., National Inst. of Fitness and Sports in Kanoya, Shiromizu, Kanoya 891-2393, JPN) ,  LI Meng Xian (Dep. of Molecular Metabolism and Biochemical Genetics, Kagoshima Univ. Graduate School of Medical and Dental ...) ,  HORIUCHI Masahisa (Dep. of Molecular Metabolism and Biochemical Genetics, Kagoshima Univ. Graduate School of Medical and Dental ...) ,  NAKAGAWA Shiro (Lab. for Neuroanatomy, Kagoshima Univ. Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima ...) ,  SAKATA Mie (Waseda-Olympus Bioscience Res. Inst., Waseda Univ., 11 Biopolis Way, Singapore 138667, SGP) ,  KUCHIIWA Satoshi (Lab. for Neuroanatomy, Kagoshima Univ. Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima ...) ,  KUCHIIWA Toshiko (Lab. for Neuroanatomy, Kagoshima Univ. Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima ...) ,  JALIL Md. Abdul (Dep. of Molecular Metabolism and Biochemical Genetics, Kagoshima Univ. Graduate School of Medical and Dental ...) ,  JALIL Md. Abdul (Lab. for Neuroanatomy, Kagoshima Univ. Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima ...) ,  BEGUM Laila (Dep. of Molecular Metabolism and Biochemical Genetics, Kagoshima Univ. Graduate School of Medical and Dental ...) ,  LU Yao Bang (Dep. of Molecular Metabolism and Biochemical Genetics, Kagoshima Univ. Graduate School of Medical and Dental ...) ,  IIJIMA Mikio (Dep. of Molecular Metabolism and Biochemical Genetics, Kagoshima Univ. Graduate School of Medical and Dental ...) ,  HANADA Takeshi (Dep. of Internal Medicine, Miyazaki Medical Coll., Univ. of Miyazaki, 5200 Kihara, Kiyotake 889-1692, JPN) ,  NAKAZATO Masamitsu (Dep. of Internal Medicine, Miyazaki Medical Coll., Univ. of Miyazaki, 5200 Kihara, Kiyotake 889-1692, JPN) ,  HUANG Zhi-li (Dep. of Molecular Behavioral Biology, Osaka Bioscience Inst., Osaka 565-0874, JPN) ,  EGUCHI Naomi (Waseda-Olympus Bioscience Res. Inst., Waseda Univ., 11 Biopolis Way, Singapore 138667, SGP) ,  EGUCHI Naomi (Dep. of Molecular Behavioral Biology, Osaka Bioscience Inst., Osaka 565-0874, JPN) ,  KOBAYASHI Keiko (Dep. of Molecular Metabolism and Biochemical Genetics, Kagoshima Univ. Graduate School of Medical and Dental ...) ,  SAHEKI Takeyori (Dep. of Molecular Metabolism and Biochemical Genetics, Kagoshima Univ. Graduate School of Medical and Dental ...)
Material： Neuroscience Research  (神経科学)
Volume： 55  Issue： 1  Page： 78-86  Publication year： May. 2006 
JST Material Number： D0210C  ISSN： 0168-0102  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *metabolic disease ,...
Semi thesaurus term： slow wave sleep ,...

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JST classification (1)： Central nervous system  (EJ12030F)

Substance index (3)： Carnitine ,  Orexin A ,  Modafinil

Reference (46)：

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• Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou, T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B., Scammell, T. E., 2001. Fos expression in orexin neurons varies with behavioral state. J. Neurosci.21, 1656-1662.
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• Fujiki, N., Yoshida, Y., Ripley, B., Honda, K., Mignot, E., Nishino, S., 2001. Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 h and in response to food deprivation. NeuroReport 12, 993-997.
• Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K., Goto, K., Yanagisawa, M., Sakurai, T., 2001. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30, 345-354.

Terms in the title (6)： カルニチン欠乏 ,  マウス ,  絶食 ,  自発運動 ,  オレキシンニューロン ,  反応低下