Art

J-GLOBAL ID：200902206850146968   Reference number：04A0093666

A Synthesis of Heteroaromatic Analogues of 1-Methyl-1,2,3,4-tetrahydroisoquinoline Using the Pummerer-Type Cyclization Reaction: Observation of Tandem Cyclization Reaction

Pummerer型環化反応を用いる1-メチル-1,2,3,4-テトラヒドロイソキノリンのヘテロ芳香族類似体の合成: 逐次環化反応の観測

Author (4)： HORIGUCHI Y (Showa Pharmaceutical Univ., Tokyo, JPN) ,  OGAWA K (Showa Pharmaceutical Univ., Tokyo, JPN) ,  SAITOH T (Showa Pharmaceutical Univ., Tokyo, JPN) ,  SANO T (Showa Pharmaceutical Univ., Tokyo, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 52  Issue： 2  Page： 214-220  Publication year： Feb. 01, 2004 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *nitrogen heterocyclic compound ,...
Semi thesaurus term： bridged compound ,...

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JST classification (2)： Other condensed derivatives of pyridine  (CF07097Y) ,  Cyclization reaction,ring-opening reaction  (CF02050I)

Substance index (20)： 2-Acetylfuran ,  2-Acetylthiophene ,  2-Acetylbenzofuran ,  2-Acetylbenzo(b)thiophene ,  2-(Phenylthio)ethanamine ,  4,5,6,7-Tetrahydrothieno[2,3-c]pyridine-6-carbaldehyde ,  1-Methyl-1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridine ,  N-[1-(2-Thienyl)ethyl]-N-[2-(phenylsulfinyl)ethyl]formamide ,  N-[1-(2-Benzofuryl)ethyl]-N-[2-(phenylsulfinyl)ethyl]formamide ,  N-[1-(1-Benzothiophene-2-yl)ethyl]-N-[2-(phenylsulfinyl)ethyl]formamide ,  4-(Phenylthio)-7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-6-carbaldehyde ,  7-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-6-carbaldehyde ,  3,4-Dihydro-1-methyl-4-(phenylthio)benzofuro[2,3-c]pyridine-2(1H)-carbaldehyde ,  1-Methyl-4-(phenylthio)-1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridine-2-carbaldehyde ,  (1R)-1β-Methyl-4β,9aβ-[thio(1,2-phenylene)]-1,2,3,4,4aα,9a-hexahydrobenzofuro[2,3-c]pyridine-2-carbaldehyde ,  (1R)-1β-Methyl-4α,9aα-[thio(1,2-phenylene)]-1,2,3,4,4aβ,9a-hexahydrobenzofuro[2,3-c]pyridine-2-carbaldehyde ,  (1R)-1β-Methyl-4β,9aβ-[thio(1,2-phenylene)]-1,2,3,4,4aα,9a-hexahydrobenzofuro[2,3-c]pyridine ,  (1R)-1β-Methyl-4α,9aα-[thio(1,2-phenylene)]-1,2,3,4,4aβ,9a-hexahydrobenzofuro[2,3-c]pyridine ,  1-Methyl-2-formyl-4-(phenylthio)-1,2,3,4,4a-pentahydrobenzofuro[2,3-c]pyridine-9-ium ,  Bis(trifluoroacetic acid) anhydride

Reference (17)：

• 1) Saitoh T., Shikiya K., Horiguchi Y., Sano T., Chem. Pharm. Bull., 51, 667—672 (2003).
• 2) Shinohara T., Toda J., Sano T., Chem. Pharm. Bull., 45, 813—819 (1997).
• 3) Shinohara T., Takeda A., Toda J., Terasawa N., Sano T., Heterocycles, 46, 555—565 (1997).
• 4) Shinohara T., Takeda A., Toda J., Ueda Y., Kohno M., Sano T., Chem. Pharm. Bull., 46, 918—927 (1998).
• 5) Shinohara T., Takeda A., Toda J., Sano T., Chem. Pharm. Bull., 46, 430—433 (1998).

Terms in the title (5)： 環化反応 ,  テトラヒドロイソキノリン ,  芳香族 ,  類似体 ,  観測