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J-GLOBAL ID：200902209995520670   Reference number：07A0135213

Structure-Activity Relationship Study of the Bacterial Actin-Like Protein MreB Inhibitors: Effects of Substitution of Benzyl Group in S-Benzylisothiourea

細菌のアクチン様蛋白質MreB阻害剤の構造活性相関: S-ベンジルイソチオ尿素におけるベンジル基の置換の影響

Author (6)： IWAI Noritaka (Dep. of Bioengineering, Tokyo Inst. of Technol.) ,  IWAI Noritaka (Frontier Collaborative Res. Center, Tokyo Inst. of Technol.) ,  FUJII Takuya (Dep. of Bioengineering, Tokyo Inst. of Technol.) ,  NAGURA Hirokatsu (Dep. of Bioengineering, Tokyo Inst. of Technol.) ,  WACHI Masaaki (Dep. of Bioengineering, Tokyo Inst. of Technol.) ,  KITAZUME Tomoya (Dep. of Bioengineering, Tokyo Inst. of Technol.)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 71  Issue： 1  Page： 246-248 (J-STAGE)  Publication year： 2007 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： benzyl group ,...
Semi thesaurus term： Escherichia coli ,...

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JST classification (1)： Basic research of antibacterial drugs  (GW17020S)

Substance index (6)： 2-Benzylisothiourea ,  2-(2-Chlorobenzyl)isothiourea ,  2-(4-Chlorobenzyl)isothiourea ,  2-(4-Bromobenzyl)isothiourea ,  RRD-251 ,  A-22

Reference (9)：

• 1) Wachi, M., Iwai, N., Kunihisa, A., and Nagai, K., Irregular nuclear localization and anucleate cell production in Escherichia coli induced by a Ca²⁺ chelator, EGTA. Biochimie, 81, 909–913 (1999).
• 2) Iwai, N., Nagai, K., and Wachi, M., Novel S-benzylisothiourea compound that induces spherical cells in Escherichia coli probably by acting on a rod-shape-determining protein(s) other than penicillin-binding protein 2. Biosci. Biotechnol. Biochem., 66, 2658–2662 (2002).
• 3) Gitai, Z., Dye, N. A., Reisenauer, A., Wachi, M., and Shapiro, L., MreB actin-mediated segregation of a specific region of a bacterial chromosome. Cell, 120, 329–342 (2005).
• 4) Kruse, T., Blagoev, B., Lobner-Olesen, A., Wachi, M., Sasaki, K., Iwai, N., Mann, M., and Gerdes, K., Actin homolog MreB and RNA polymerase interact and are both required for chromosome segregation in Escherichia coli. Genes Dev., 20, 113–124 (2006).
• 5) Iwai, N., Ebata, T., Nagura, H., Kitazume, T., Nagai, K., and Wachi, M., Structure-activity relationship of S-benzylisothiourea derivatives to induce spherical cells in Escherichia coli. Biosci. Biotechnol. Biochem., 68, 2265–2269 (2004).

Terms in the title (9)： 細菌 ,  アクチン ,  蛋白質 ,  MreB ,  阻害剤 ,  構造活性相関 ,  S-ベンジルイソチオ尿素 ,  ベンジル基 ,  置換