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J-GLOBAL ID：200902224258785328   Reference number：04A0058522

Possible Role of Interleukin-6 in PC12 Cell Death Induced by MPP⁺ and Tetrahydroisoquinoline

MPP⁺とテトラヒドロイソキノリンにより誘導されるPC12細胞死におけるインターロイキン6の可能な役割

Author (8)： SHIMMA N (Chiba Univ., Chiba, JPN) ,  AKIYAMA N (Chiba Univ., Chiba, JPN) ,  UMEZAWA M (Hokkaido Univ., Sapporo, JPN) ,  OKUMA Y (Hokkaido Univ., Sapporo, JPN) ,  NOMURA Y (Hokkaido Univ., Sapporo, JPN) ,  SAITO T (Hokkaido Univ. School of Medicine, Sapporo, JPN) ,  HORIE S (Chiba Univ., Chiba, JPN) ,  MURAYAMA T (Chiba Univ., Chiba, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 93  Issue： 4  Page： 471-477  Publication year： Dec. 01, 2003 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *neurotoxin ,...
Semi thesaurus term： NGF

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JST classification (2)： Cytokines  (EB08090G) ,  Basic neurology  (GN01020W)

Substance index (2)： 1-Methyl-4-phenylpyridinium ,  1,2,3,4-Tetrahydroisoquinoline

Reference (34)：

• 1 Nagatsu T. Isoquinoline neurotoxins in the brain and Parkinson’s disease. Neurosci Res. 1997;29:99–111.
• 2 Naoi M, Maruyama W, Akao Y, Zhang J, Parvez H. Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopamine neurons. Toxicology. 2000;153:123–141.
• 3 McNaught KSP, Thull U, Carrupt PA, et al. Toxicity to PC12 cells of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurosci Lett. 1996;206:37–40.
• 4 Kawai H, Kotake Y, Ohta S. Dopamine transporter and catechol-O-methyltransferase activities are required for the toxicity of 1-(3',4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline. Chem Res Toxicol. 2000;13,1294–1301.
• 5 Itano Y, Kitamura Y, Nomura Y. 1-Methyl-4-phenylpyridinium (MPP⁺ )-induced cell death in PC12 cells: inhibitory effects of several drugs. Neurochem Int. 1994;25:419–424.

Terms in the title (6)： MPP+ ,  テトラヒドロイソキノリン ,  誘導 ,  PC12細胞 ,  インターロイキン6 ,  役割