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J-GLOBAL ID：200902226847832045   Reference number：09A0767185

Inhibition of Collagenolytic Cathepsins by β-Lactoglobulin in Milk and Its Suppressive Effect on Bone Resorption

牛乳中のβ-ラクトグロブリンによるコラーゲン溶解性のカテプシン類の阻害およびβ-ラクトグロブリンの骨吸収に及ぼす抑制効果

Author (5)： OGAWA Naoko (Fac. of Life Sci., Tokushima Bunri Univ.) ,  TAKAHASHI Masae (Inst. for Health Sciences, Tokushima Bunri Univ.) ,  ISHIDOH Kazumi (Fac. of Life Sci., Tokushima Bunri Univ.) ,  ISHIDOH Kazumi (Inst. for Health Sciences, Tokushima Bunri Univ.) ,  KATUNUMA Nobuhiko (Inst. for Health Sciences, Tokushima Bunri Univ.)
Material： Journal of Nutritional Science and Vitaminology  (Nutritional Science and Vitaminology)
Volume： 55  Issue： 3  Page： 264-270 (J-STAGE)  Publication year： 2009 
JST Material Number： F0733A  ISSN： 0301-4800  CODEN： JNSVA5  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cow milk ,...
Semi thesaurus term： cathepsin K inhibitor ,...

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JST classification (4)： Preventive medicine in general  (GB01010B) ,  Food chemistry,nutritional value  (FJ01020J) ,  Raw milk quality and treatments  (FJ12022D) ,  Skeletal system  (EJ10030R)

Reference (14)：

• KATUNUMA, N. New drug design for preventing bone resorption. The Sixth International Forum on Calcified Tissue and Bone Metabolism, 1997. 1997, 42-47
• KATUNUMA, N. Mechanism and regulation of bone resorption by osteoclasis. Curr Top Cell Regul. 1997, 35, 179-192
• KATUNUMA, N. Molecular mechanism of bone collagen degradation in bone resorption. J Bone Miner Metab. 1997, 15, 1-8
• KATUNUMA, N. Structure-based development of pyridoxal propionate derivatives as specific inhibitors of cathepsin K in vitro and in vivo. Biochem Biophys Res Commun. 2000, 27, 850-854
• OHASHI, A. New function of lactoferrin and β-casein in mammalian milk as cysteine protease inhibitors. Biochem Biophys Res Commun. 2003, 306, 98-103

Terms in the title (8)： 牛乳 ,  β-ラクトグロブリン ,  コラーゲン ,  溶解性 ,  カテプシン ,  阻害 ,  骨吸収 ,  抑制効果