Art
J-GLOBAL ID：200902227301086349   Reference number：08A0959811

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote mlignancy

NRF2の癌関連の突然変異は,Keap1-Cul3 E3リガーゼによる認識を損ない,悪性腫瘍を促進させる
Author (12)：
SHIBATA Tatsuhiro

About SHIBATA Tatsuhiro

(National Cancer Center Res. Inst., Tokyo, JPN)

About National Cancer Center Res. Inst., Tokyo, JPN

, 
OHTA Tsutomu

About OHTA Tsutomu

(National Cancer Center Res. Inst., Tokyo, JPN)

About National Cancer Center Res. Inst., Tokyo, JPN

, 
TONG Kit I.

About TONG Kit I.

(JST-ERATO)

About JST-ERATO

, 
TONG Kit I.

About TONG Kit I.

(Univ. Tsukuba, Tsukuba, JPN)

About Univ. Tsukuba, Tsukuba, JPN

, 
KOKUBU Akiko

About KOKUBU Akiko

(National Cancer Center Res. Inst., Tokyo, JPN)

About National Cancer Center Res. Inst., Tokyo, JPN

, 
ODOGAWA Reiko

About ODOGAWA Reiko

(National Cancer Center Res. Inst., Tokyo, JPN)

About National Cancer Center Res. Inst., Tokyo, JPN

, 
TSUTA Koji

About TSUTA Koji

(National Cancer Center Hospital, Tokyo, JPN)

About National Cancer Center Hospital, Tokyo, JPN

, 
ASAMURA Hisao

About ASAMURA Hisao

(National Cancer Center Hospital, Tokyo, JPN)

About National Cancer Center Hospital, Tokyo, JPN

, 
YAMAMOTO Masayuki

About YAMAMOTO Masayuki

(JST-ERATO)

About JST-ERATO

, 
YAMAMOTO Masayuki

About YAMAMOTO Masayuki

(Univ. Tsukuba, Tsukuba, JPN)

About Univ. Tsukuba, Tsukuba, JPN

, 
YAMAMOTO Masayuki

About YAMAMOTO Masayuki

(Tohoku Univ. Graduate School of Medicine, Sendai, JPN)

About Tohoku Univ. Graduate School of Medicine, Sendai, JPN

, 
HIROHASHI Setsuo

About HIROHASHI Setsuo

(National Cancer Center Res. Inst., Tokyo, JPN)

About National Cancer Center Res. Inst., Tokyo, JPN


Material：
Proceedings of the National Academy of Sciences of the United States of America  (PNAS)

About Proceedings of the National Academy of Sciences of the United States of America


Volume： 105  Issue： 36  Page： 13568-13573  Publication year： Sep. 09, 2008 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)
Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
DNA binding protein

About DNA binding protein

, 
transcription factor

About transcription factor

, 
*tumor

About tumor

, 
mutation

About mutation

, 
ligase

About ligase

, 
human(primates)

About human(primates)

, 
smoking(tobacco)

About smoking(tobacco)

, 
squamous cell carcinoma

About squamous cell carcinoma

, 
down-regulation

About down-regulation

, 
oxidative stress

About oxidative stress

, 
drug therapy

About drug therapy


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*NRF2

About NRF2

, 
*malignant tumor

About malignant tumor


JST classification (1)：
JST classification
Category name(code) classified by JST.
Basic oncology in general 
(GE02010R)

About Basic oncology in general

Terms in the title (7)：
Terms in the title
Keywords automatically extracted from the title.
NRF2

About NRF2

, 
癌

About 癌

, 
突然変異

About 突然変異

, 
Keap1

About Keap1

, 
E3リガーゼ

About E3リガーゼ

, 
悪性腫瘍

About 悪性腫瘍

, 
促進

About 促進


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