Art

J-GLOBAL ID：200902240413956768   Reference number：07A0844546

A Long-lived o-Semiquinone Radical Anion is Formed from N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), an Insect-derived Antibacterial Substance

長寿命o-セミキノンラジカルアニオンは,昆虫由来抗細菌物質であるN-β-アラニル-5-S-グルタチオニル-3,4-ジヒドロキシフェニルアラニン(5-S-GAD)から形成される

Author (13)： AKIYAMA Nobuko (RIKEN, Saitama) ,  NAKANISHI Ikuo (National Inst. of Radiological Sci. (NIRS), Chiba) ,  NAKANISHI Ikuo ,  OHKUBO Kei ,  SATOH Kazue (Showa Univ., Tokyo) ,  TSUCHIYA Koichiro (Univ. Tokushima, Tokushima) ,  NISHIKAWA Takeshi (RIKEN, Saitama) ,  FUKUZUMI Shunichi ,  IKOTA Nobuo (National Inst. of Radiological Sci. (NIRS), Chiba) ,  OZAWA Toshihiko (National Inst. of Radiological Sci. (NIRS), Chiba) ,  OZAWA Toshihiko (Tohoku Univ., Miyagi, JPN) ,  TSUJIMOTO Masafumi (RIKEN, Saitama) ,  NATORI Shunji (RIKEN, Saitama)
Material： Journal of Biochemistry  (J Biochem)
Volume： 142  Issue： 1  Page： 41-48  Publication year： Jul. 01, 2007 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Hydrogen Peroxide ,...

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Physical analysis of radicals in organic substances  (CC03033J)

Substance index (2)： 2-Hydroxyphenoxy radical ,  5-S-GAD

Reference (26)：

• LEEM, J. Y. Purification and characterization of N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine, a novel antibacterial substance of Sarcophaga peregrina (flesh fly). J. Biol. Chem. 1996, 271, 13573-13577
• AKIYAMA, N. Anti-tumor effect of N-β-alanyl-5-S-glutathionyl-dihydroxyphenylalanine (5-S-GAD), a novel anti-bacterial substance from an insect. Anticancer Res. 2000, 20, 357-362
• AKIYAMA, N. Involvement of H_2O_2 and O^<・->_2 in the cytotoxicity of N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), a novel insect-derived anti-tumor compound. Cancer Sci. 2003, 94, 400-404
• NISHIKAWA, T. Correlation between the catalase level in tumor cells and their sensitivity to N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD). J. Biochem. 2004, 135, 465-469
• BINDOLI, A. Biochemical and toxicological properties of the oxidation products o-catecholamines. Free Rad. Biol. Med. 1992, 13, 391-405

Terms in the title (6)： 長寿命 ,  昆虫 ,  抗細菌 ,  物質 ,  ジヒドロキシフェニルアラニン ,  5-S-GAD