Art

J-GLOBAL ID：200902250523472397   Reference number：09A1052176

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

慢性C型肝炎に対するペグ化インターフェロンαとリバビリンの併用療法の反応性にIL28Bがゲノムワイドな関連を示す

Author (30)： TANAKA Yasuhito (Nagoya City Univ. Graduate School of Medical Sci., Nagoya, JPN) ,  NISHIDA Nao (Univ. Tokyo, Tokyo, JPN) ,  SUGIYAMA Masaya (Nagoya City Univ. Graduate School of Medical Sci., Nagoya, JPN) ,  KUROSAKI Masayuki (Musashino Red Cross Hospital, Tokyo, JPN) ,  MATSUURA Kentaro (Nagoya City Univ. Graduate School of Medical Sci., Nagoya, JPN) ,  SAKAMOTO Naoya (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  NAKAGAWA Mina (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  KORENAGA Masaaki (Kawasaki Medical Coll., Kurashiki, JPN) ,  HINO Keisuke (Kawasaki Medical Coll., Kurashiki, JPN) ,  HIGE Shuhei (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN) ,  ITO Yoshito (Kyoto Prefectural Univ. Medicine, Kyoto, JPN) ,  MITA Eiji (National Hospital Organization Osaka National Hospital, Osaka, JPN) ,  TANAKA Eiji (Shinshu Univ. School of Medicine, Matsumoto, JPN) ,  MOCHIDA Satoshi (Saitama Medical Univ., Saitama, JPN) ,  MURAWAKI Yoshikazu (Tottori Univ., Yonago, JPN) ,  HONDA Masao (Kanazawa Univ. Graduate School of Medicine, Kanazawa, JPN) ,  SAKAI Akito (Kanazawa Univ. Graduate School of Medicine, Kanazawa, JPN) ,  HIASA Yoichi (Ehime Univ. Graduate School of Medicine, Ehime, JPN) ,  NISHIGUCHI Shuhei (Hyogo Coll. of Medicine, Nishinomiya, JPN) ,  KOIKE Asako (Hitachi Ltd., Kokubunji, JPN) ,  SAKAIDA Isao (Yamaguchi Univ. Graduate School of Medicine, Yamaguchi, JPN) ,  IMAMURA Masatoshi (International Medical Center of Japan Konodai Hospital, Ichikawa, JPN) ,  ITO Kiyoaki (International Medical Center of Japan Konodai Hospital, Ichikawa, JPN) ,  YANO Koji (International Medical Center of Japan Konodai Hospital, Ichikawa, JPN) ,  MASAKI Naohiko (International Medical Center of Japan Konodai Hospital, Ichikawa, JPN) ,  SUGAUCHI Fuminaka (Nagoya City Univ. Graduate School of Medical Sci., Nagoya, JPN) ,  IZUMI Namiki (Musashino Red Cross Hospital, Tokyo, JPN) ,  TOKUNAGA Katsushi (Univ. Tokyo, Tokyo, JPN) ,  MIZOKAMI Masashi (Nagoya City Univ. Graduate School of Medical Sci., Nagoya, JPN) ,  MIZOKAMI Masashi (International Medical Center of Japan Konodai Hospital, Ichikawa, JPN)
Material： Nature Genetics  (Nat Genet)
Volume： 41  Issue： 10  Page： 1105-1109  Publication year： Oct. 2009 
JST Material Number： W0430A  ISSN： 1061-4036  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *gene ,  human ,  genetic technique ,  analysis ,  interferon alpha ,  antiviral drug ,  hepatitis C virus ,  single nucleotide polymorphism ,  autosome ,  interleukin ,  *chronic hepatitis C ,  combination therapy ,  nitrogen heterocyclic compound ,  ribonucleoside ,  carboxamide ,  Genome-Wide Association Study ,  *IL28B gene ,  interleukin 28B ,  chromosome 19 ,  microorganism
Semi thesaurus term： SNP

JST classification (2)： Genetic variation  (EC01030Y) ,  Physiology and pathogenicity of virus infection  (EG04042Y)

Substance index (1)： Ribavirin

Terms in the title (7)： 慢性C型肝炎 ,  インターフェロンα ,  リバビリン ,  併用療法 ,  反応性 ,  IL28B ,  ゲノム