Art

J-GLOBAL ID：200902255711870318   Reference number：04A0642415

Absolute stereochemistries and total synthesis of (+)-arisugacins A and B, potent, orally bioactive and selective inhibitors of acetylcholinesterase

経口的に生物活性があり強力な選択的アセチルコリンエステラーゼの阻害剤,(+)-アリスガシンA及びBの絶対立体化学及び全合成

Author (8)： SUNAZUKA T (Kitasato Univ., Tokyo, JPN) ,  HANDA M (Kitasato Univ., Tokyo, JPN) ,  NAGAI K (Kitasato Univ., Tokyo, JPN) ,  SHIRAHATA T (Kitasato Inst., Tokyo, JPN) ,  HARIGAYA Y (Kitasato Univ., Tokyo, JPN) ,  OTOGURO K (Kitasato Inst., Tokyo, JPN) ,  KUWAJIMA I (Kitasato Univ., Tokyo, JPN) ,  OMURA S (Kitasato Univ., Tokyo, JPN)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 60  Issue： 36  Page： 7845-7859  Publication year： Aug. 30, 2004 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： Acetylcholinesterase ,...
Semi thesaurus term： dihydroxylation ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=04A0642415&from=J-GLOBAL&jstjournalNo=E0234A") }}

JST classification (2)： Other natural substances of biological origin  (CF10090R) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (14)： Arisugacin A ,  Arisugacin B ,  2-Pyrone ,  4-Hydroxy-6-(3,4-dimethoxyphenyl)-2H-pyran-2-one ,  4-Hydroxy-6-(4-methoxyphenyl)-2H-pyran-2-one ,  (8S)-5,5,8aβ-Trimethyl-8α-hydroxy-3,5,6,7,8,8a-hexahydronaphthalene-1-carboxylic acid 1,8-lactone ,  2,4,4-Trimethyl-3-vinyl-2-cyclohexen-1-one ,  (4S)-4α,4aα-Epoxy-5,5,8aβ-trimethyl-8α-hydroxy-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid 1,8-lactone ,  2,5,5,8aβ-Tetramethyl-4aα,8α-dihydroxy-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carbaldehyde ,  (1S)-1β,4aβ-Dihydroxy-4,4,6aα,12bα-tetramethyl-9-(3,4-dimethoxyphenyl)-1,2,3,4a,5,6,6a,12b-octahydro-4H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one ,  1α-Acetoxy-4,4,6aα,12bα-tetramethyl-4aβ,12β,12aβ-trihydroxy-9-(3,4-dimethoxyphenyl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one ,  (1R)-1α,4aβ,12aβ-Trihydroxy-4,4,6aα,12bα-tetramethyl-9-(3,4-dimethoxyphenyl)-1,2,3,4a,5,6,6a,12,12a,12b-decahydro-4H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one ,  (4aR)-4,4,6aα,12bα-Tetramethyl-4aβ,12aβ-dihydroxy-9-(3,4-dimethoxyphenyl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-1,11-dione ,  (1S)-1β,4aβ-Dihydroxy-4,4,6aα,12bα-tetramethyl-9-(4-methoxyphenyl)-1,2,3,4a,5,6,6a,12b-octahydro-4H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one

Terms in the title (6)： 生物活性 ,  アセチルコリンエステラーゼ ,  阻害剤 ,  アリスガシンA ,  立体化学 ,  全合成