Art

J-GLOBAL ID：200902257339339093   Reference number：08A0860586

Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma: Application to Pharmacokinetic Studies

ヒト血漿におけるクワの実の1-デオキシノジリマイシンのイオン捕獲型タンデム質量分析の検証:薬物動態研究への応用

Author (7)： NAKAGAWA Kiyotaka (Food and Biodynamic Chemistry Lab., Graduate School of Agricultural Sci., Tohoku Univ.) ,  KUBOTA Hiroyuki (Food and Biodynamic Chemistry Lab., Graduate School of Agricultural Sci., Tohoku Univ.) ,  TSUZUKI Tsuyoshi (Food and Biodynamic Chemistry Lab., Graduate School of Agricultural Sci., Tohoku Univ.) ,  KARIYA Jun (Project M Co., Ltd.) ,  KIMURA Toshiyuki (National Agricultural Res. Center for Tohoku Region) ,  OIKAWA Shinichi (Dep. of Medicine, Nippon Medical School) ,  MIYAZAWA Teruo (Food and Biodynamic Chemistry Lab., Graduate School of Agricultural Sci., Tohoku Univ.)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 72  Issue： 8  Page： 2210-2213 (J-STAGE)  Publication year： 2008 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *イオン捕獲型タンデム質量分析

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JST classification (2)： Clinical biopharmacy  (GY01022L) ,  Clinical application of drugs acting on carbohydrate metabolism  (GW13030B)

Substance index (1)： 1-Deoxynojirimycin

Reference (15)：

• 1) Asano, N., Nash, R. J., Molyneux, R. J., and Fleet, G. W. J., Sugar-mimic glycosidase inhibitors: natural occurrence, biological activity and prospects for therapeutic application. Tetrahedron: Asymmetry, 11, 1645–1680 (2000).
• 2) Mudra, M., Ercan-Fang, N., Zhong, L., Furne, J., and Levitt, M., Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care, 30, 1272–1274 (2007).
• 3) Kimura, T., Nakagawa, K., Saito, Y., Yamagishi, K., Suzuki, M., Yamaki, K., Shinmoto, H., and Miyazawa, T., Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection. J. Agric. Food Chem., 52, 1415–1418 (2004).
• 4) Kimura, T., Nakagawa, K., Kubota, H., Kojima, Y., Goto, Y., Yamagishi, K., Oita, S., Oikawa, S., and Miyazawa, T., Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in human. J. Agric. Food Chem., 55, 5869–5874 (2007).
• 5) Nakagawa, K., Kubota, H., Kimura, T., Yamashita, S., Tsuzuki, T., Oikawa, S., and Miyazawa, T., Occurrence of orally administered mulberry 1-deoxynojirimycin in rat plasma. J. Agric. Food Chem., 55, 8928–8933 (2007).

Terms in the title (11)： ヒト ,  血漿 ,  クワ ,  実 ,  1-デオキシノジリマイシン ,  イオン捕獲 ,  タンデム質量分析 ,  検証 ,  薬物動態 ,  研究 ,  応用