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J-GLOBAL ID：200902262662004266   Reference number：06A0338309

RECS1 is a Negative Regulator of Matrix Metalloproteinase-9 Production and Aged RECS1 Knockout Mice are Prone to Aortic Dilation

RECS1はマトリックスメタロプロテアーゼ-9の負のレギュレーターであり,高齢RECS1ノックアウトマウスは大動脈拡張の傾向を示す

Author (7)： ZHAO Hanjun (Dep. of Cardiovascular Medicine, Graduate School of Medicine, Osaka Univ.) ,  ZHAO Hanjun (Dep. of Molecular Genetics, Res. Inst. for Microbial Diseases, Osaka Univ.) ,  ITO Akihiko (Div. of Surgical Pathology, Graduate School of Medicine, Kobe Univ.) ,  SAKAI Naohiko (Dep. of Cardiovascular Medicine, Graduate School of Medicine, Osaka Univ.) ,  MATSUZAWA Yuji (Sumitomo Hospital and Osaka Univ.) ,  YAMASHITA Shizuya (Dep. of Cardiovascular Medicine, Graduate School of Medicine, Osaka Univ.) ,  NOJIMA Hiroshi (Dep. of Molecular Genetics, Res. Inst. for Microbial Diseases, Osaka Univ.)
Material： Circulation Journal  (Circ J)
Volume： 70  Issue： 5  Page： 615-624 (J-STAGE)  Publication year： 2006 
JST Material Number： F0908A  ISSN： 1346-9843  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： knockout mouse ,...
Semi thesaurus term： *gelatinase ,...

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JST classification (2)： Gene expression  (EC02040Q) ,  Basic medicine on cardiovascular system  (GJ01020K)

Reference (24)：

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• 2. Higo S, Uematsu M, Yamagishi M, Ishibashi-Ueda H, Awata M, Morozumi T, et al. Elevation of plasma matrix metalloproteinase-9 in the culprit coronary artery in patients with acute myocardial infarction: Clinical evidence from distal protection. Circ J 2005; 69: 1180-1185.
• 3. Noji Y, Shimizu M, Ino H, Higashikata T, Yamaguchi M, Nohara A, et al. Increased circulating matrix metalloproteinase-2 in patients with hypertrophic cardiomyopathy with systolic dysfunction. Circ J 2004; 68: 355-360.
• 4. Patel MI, Melrose J, Ghosh P, Appleberg M. Increased synthesis of matrix metalloproteinases by aortic smooth muscle cells is implicated in the etiopathogenesis of abdominal aortic aneurysms. J Vasc Surg 1996; 24: 82-92.
• 5. Bunton TE, Biery NJ, Myers L, Gayraud B, Ramirez F, Dietz HC. Phenotypic alteration of vascular smooth muscle cells precedes elastolysis in a mouse model of Marfan syndrome. Circ Res 2001; 88: 37-43.

Terms in the title (5)： マトリックスメタロプロテアーゼ ,  レギュレーター ,  ノックアウトマウス ,  大動脈拡張 ,  傾向