Art

J-GLOBAL ID：200902263638999261   Reference number：04A0073382

Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation

多プロモーターCpGアイランドにおける高頻度の低メチル化は全体的低メチル化と関係するが,高頻度のプロモーター高メチル化とは関係しない

Author (8)： KANEDA A (National Cancer Center Res. Inst., Tokyo) ,  TSUKAMOTO T (Aichi Cancer Center Res. Inst., Aichi) ,  TAKAMURA-ENYA T (National Cancer Center Res. Inst., Tokyo) ,  WATANABE N (National Cancer Center Res. Inst., Tokyo) ,  KAMINISHI M (Univ. Tokyo, Tokyo) ,  SUGIMURA T (National Cancer Center Res. Inst., Tokyo) ,  TATEMATSU M (Aichi Cancer Center Res. Inst., Aichi) ,  USHIJIMA T (National Cancer Center Res. Inst., Tokyo)
Material： Cancer Science  (Cancer Sci)
Volume： 95  Issue： 1  Page： 58-64  Publication year： Jan. 31, 2004 
JST Material Number： F0633A  ISSN： 1347-9032  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： 高メチル化

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JST classification (1)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (24)：

• GAMA-SOSA, MA. The 5-methylcytosine content of DNA from human tumors. Nucl Acids Res. 1983, 11, 6883-6894
• FEINBERG, AP. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature. 1983, 301, 89-92
• JURGENS, B. Hypomethylation of L1 LINE sequences prevailing in human urothelial carcinoma. Cancer Res. 1996, 56, 5698-5703
• TAKAI, D. Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis. Jpn J Clin Oncol. 2000, 30, 306-309
• DUNN, BK. Hypomethylation : one side of a larger picture. Ann N Y Acad Sci. 2003, 983, 28-42

Terms in the title (5)： プロモーター ,  CpGアイランド ,  頻度 ,  低メチル化 ,  プロモーター高メチル化