Art

J-GLOBAL ID：200902264574085178   Reference number：09A0924909

The first total synthesis of nidulalin A, a dihydroxanthone possessing multiple bioactivities

多様な生物活性を有するジヒドロキサントン,ニズラリンAの初めての全合成

Author (5)： TATSUTA Kuniaki (Waseda Univ., Tokyo, JPN) ,  YOSHIHARA Shusuke (Waseda Univ., Tokyo, JPN) ,  HATTORI Nobutaka (Waseda Univ., Tokyo, JPN) ,  YOSHIDA Shinpei (Waseda Univ., Tokyo, JPN) ,  HOSOKAWA Seijiro (Waseda Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 62  Issue： 8  Page： 469-470  Publication year： Aug. 2009 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *total synthesis ,...
Semi thesaurus term： Emericella ,...

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JST classification (1)： Synthesis of antibiotics  (GX04000Z)

Substance index (1)： Nidulalin A

Reference (12)：

• KAWAHARA, N. Structure of a new dihydroxanthone derivative, nidulalin A, and a new benzophenone derivative, nidulalin B, from Emericella nidulans. Chem. Pharm. Bull. 1994, 42, 1720-1723
• SATO, S. Synthesis of novel antitumor dihydroxanthone derivatives with inhibitory activity against DNA topoisomerase II. Bioorg. Med. Chem. Lett. 1999, 9, 2653-2656
• FUJIMOTO, H. Nine constituents including six xanthone-related compounds isolated from Two ascomycetes, Gelasinospora santiflorii and Emericella quadrilineata, Found in a screening study focused on immunomodulatory activity. Chem. Pharm. Bull. 2006, 54, 550-553
• TABATA, N. Structure and biosynthesis of xanthoquinodins, anticoccidial antibiotics. J. Am. Chem. Soc. 1992, 115, 8558-8564
• PARISH, C. A. Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation. J. Am. Chem. Soc. 2008, 130, 7060-7066

Terms in the title (3)： 生物活性 ,  ニズラリンA ,  全合成