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J-GLOBAL ID：200902268125528842   Reference number：07A0281179

Characterization of neuron-specific huntingtin aggregates in human huntingtin knock-in mice

ヒトハンチンチンノックインマウスにおけるニューロン特異的ハンチンチン凝集体の特徴

Author (13)： SAWADA Hirohide (Inst. for Comprehensive Medical Sci., Fujita Health Univ., 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi ...) ,  ISHIGURO Hiroshi (Inst. for Comprehensive Medical Sci., Fujita Health Univ., 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi ...) ,  ISHIGURO Hiroshi (Carna Biosciences Inc., Kobe, Hyogo 650-0047, JPN) ,  NISHII Kazuhiro (Inst. for Comprehensive Medical Sci., Fujita Health Univ., 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi ...) ,  NISHII Kazuhiro (Education and Res. Center of Animal Models for Human Diseases, Fujita Health Univ., Toyoake, Aichi 470-1192, JPN) ,  YAMADA Kouji (Inst. for Comprehensive Medical Sci., Fujita Health Univ., 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi ...) ,  YAMADA Kouji (Fac. of Rehabilitation, School of Health Sciences, Fujita Health Univ., Toyoake, Aichi 470-1192, JPN) ,  TSUCHIDA Kunihiro (Inst. for Comprehensive Medical Sci., Fujita Health Univ., 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi ...) ,  TAKAHASHI Hisahide (Education and Res. Center of Animal Models for Human Diseases, Fujita Health Univ., Toyoake, Aichi 470-1192, JPN) ,  GOTO Jun (Dep. of Neurology, Div. of Neuroscience, Graduate School of Medicine, Univ. of Tokyo, Tokyo 113-8655, JPN) ,  KANAZAWA Ichiro (Dep. of Neurology, Div. of Neuroscience, Graduate School of Medicine, Univ. of Tokyo, Tokyo 113-8655, JPN) ,  KANAZAWA Ichiro (National Inst. of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, JPN) ,  NAGATSU Toshiharu (Inst. for Comprehensive Medical Sci., Fujita Health Univ., 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi ...)
Material： Neuroscience Research  (神経科学)
Volume： 57  Issue： 4  Page： 559-573  Publication year： Apr. 2007 
JST Material Number： D0210C  ISSN： 0168-0102  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *protein ,...
Semi thesaurus term： *Huntington's chorea ,...

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JST classification (2)： Central nervous system  (EJ12030F) ,  Basic neurology  (GN01020W)

Reference (58)：

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• Cicchetti, F., Prensa, L., Wu, Y., Parent, A., 2000. Chemical anatomy of striatal intemeurons in normal individuals and in patients with Huntington’s disease. Brain Res. Brain Res. Rev.34, 80-101.
• Davies, S. W., Turmaine, M., Cozens, B. A., DiFiglia, M., Sharp, A. H., Ross, C. A., Scherzinger, E., Wanker, E. E., Mangiarini, L., Bates, G. P., 1997. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90, 537-548.
• DiFiglia, M., Sapp, E., Chase, K., Schwarz, C., Meloni, A., Young, C., Martin, E., Vonsattel, Carraway, R., Reeves, S. A., Boyce, F. M., Aronin, N., 1995. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 14, 1075-1081.

Terms in the title (3)： ニューロン ,  ハンチンチン ,  凝集体