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J-GLOBAL ID：200902268811296575   Reference number：09A0194617

Marked increases in hippocampal neuron indoleamine 2, 3-dioxygenase via IFN-γ-independent pathway following transient global ischemia in mouse

一過性全脳虚血後のマウス海馬ニューロンにおけるIFN-γ-非依存性の経路を介するインドールアミン2,3-ジオキシゲナーゼの顕著な増大

Author (11)： HOSHI Masato (Dep. of Informative Clinical Medicine, Gifu Univ. Graduate School of Medicine, Gifu City, JPN) ,  SAITO Kuniaki (Dep. of Informative Clinical Medicine, Gifu Univ. Graduate School of Medicine, Gifu City, JPN) ,  SAITO Kuniaki (Human Health Sciences, Kyoto Univ. Graduate School of Medicine and Fac. of Medicine, Kyoto, JPN) ,  MURAKAMI Yuki (Section of Pharmacology, National Inst. of Mental Health, National Institutes of Health, Bethesda, MD, USA) ,  TAGUCHI Ayako (Dep. of Tumor Pathology, Gifu Univ. Graduate School of Medicine, Gifu City, JPN) ,  FUJIGAKI Hidetsugu (Dep. of Informative Clinical Medicine, Gifu Univ. Graduate School of Medicine, Gifu City, JPN) ,  TANAKA Ryo (Dep. of Informative Clinical Medicine, Gifu Univ. Graduate School of Medicine, Gifu City, JPN) ,  TAKEMURA Masao (Dep. of Informative Clinical Medicine, Gifu Univ. Graduate School of Medicine, Gifu City, JPN) ,  ITO Hiroyasu (Dep. of Informative Clinical Medicine, Gifu Univ. Graduate School of Medicine, Gifu City, JPN) ,  HARA Akira (Dep. of Tumor Pathology, Gifu Univ. Graduate School of Medicine, Gifu City, JPN) ,  SEISHIMA Mitsuru (Dep. of Informative Clinical Medicine, Gifu Univ. Graduate School of Medicine, Gifu City, JPN)
Material： Neuroscience Research  (神経科学)
Volume： 63  Issue： 3  Page： 194-198  Publication year： Mar. 2009 
JST Material Number： D0210C  ISSN： 0168-0102  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *transient cerebral ischemia ,...
Semi thesaurus term： *インドールアミン2,3-ジオキシゲナーゼ ,...

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JST classification (2)： Central nervous system  (EJ12030F) ,  Enzyme physiology  (EJ02020P)

Reference (21)：

• Block, F., Peters, M., Nolden-Koch, M., 2000. Expression of IL-6 in the ischemic penumbra. Neuroreport 11 (5), 963-967.
• Frumento, G., Rotondo, R., Tonetti, M., Damonte, G., Benatti, U., Ferrara, G.B., 2002. Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J. Exp. Med. 196 (4), 459-468.
• Fujigaki, S., Saito, K., Sekikawa, K., Tone, S., Takikawa, O., Fujii, H., Wada, H., Noma, A., Seishima, M., 2001. Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism. Eur. J. Immunol. 31 (8), 2313-2318.
• Fujigaki, S., Takemura, M., Hamakawa, H., Seishima, M., Saito, K., 2003. The mechanism of interferon-gamma induced anti Toxoplasma gondii by indoleamine 2,3-dioxygenase and/or inducible nitric oxide synthase vary among tissues. Adv. Exp. Med. Biol. 527, 97-103.
• Fujigaki, H., Saito, K., Fujigaki, S., Takemura, M., Sudo, K., Ishiguro, H., Seishima, M., 2006. The signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways, and synergistic effect of several proinflammatory cytokines. J. Biochem. 139 (4), 655-662.

Terms in the title (7)： 全脳虚血 ,  マウス ,  海馬ニューロン ,  IFN-γ ,  非依存性 ,  経路 ,  ジオキシゲナーゼ