Role of prorenin in the pathogenesis of retinal neovascularization

YOKOTA Harumasa; TAKAMIYA Akira; NAGAOKA Taiji; HIKICHI Taiichi; ISHIDA Yuichi; SUZUKI Fumiaki; YOSHIDA Akitoshi

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J-GLOBAL ID：200902270534425880 Reference number：08A0559151

Role of prorenin in the pathogenesis of retinal neovascularization

網膜血管新生の発症におけるプロレニンの役割

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Material：
Volume： 83 Issue： 3 Page： 159-165 Publication year： May. 01, 2008
JST Material Number： Z0749A ISSN： 0367-6102 Document type： Article
Article type：原著論文 Country of issue： Japan (JPN) Language： ENGLISH (EN)

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Basic ophthalmology

Reference (17)：

MORAVSKI, CJ. The renin-angiotensin system influences ocular endothelial cell proliferation in diabetes : transgenic and interventional studies. Am J Pathol. 2003, 162, 151-160
KIDA, T. Reninangiotensin system in proliferative diabetic retinopathy and its gene expression in cultured human muller cells. Jpn J Ophthalmol. 2003, 47, 36-41
MORAVSKI, CJ. Retinal neovascularization is prevented by blockade of the renin-angiotensin system. Hypertension. 2000, 36, 1099-1104
SUZUKI, F. Human prorenin has "gate and handle" regions for its non-proteolytic activation. J Biol Chem. 2003, 278, 22217-22222
ICHIHARA, A. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin. J Clin Invest. 2004, 114, 1128-1135

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