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J-GLOBAL ID：200902275338766352   Reference number：09A0461840

A Novel Mouse Model for Type 2 Diabetes and Non-alcoholic Fatty Liver Disease: Spontaneous Amelioration of Diabetes by Augmented Beta Cell Mass

2型糖尿病と非アルコール性脂肪性肝疾患の新しいマウスモデル:β細胞量増加による糖尿病の自然改善

Author (11)： OZE-FUKAI Aya (Dep. of Geriatric Medicine, Osaka Univ. Graduate School of Medicine) ,  FUJISAWA Tomomi (Dep. of Geriatric Medicine, Osaka Univ. Graduate School of Medicine) ,  SUGIMOTO Ken (Dep. of Geriatric Medicine, Osaka Univ. Graduate School of Medicine) ,  NOJIMA Koji (Dep. of Geriatric Medicine, Osaka Univ. Graduate School of Medicine) ,  SHINDO Nobuyasu (Dep. of Geriatric Medicine, Osaka Univ. Graduate School of Medicine) ,  SHIMOYOSHI Satomi (Dep. of Geriatric Medicine, Osaka Univ. Graduate School of Medicine) ,  YOSHIKAWA Yuki (Dep. of Geriatric Medicine, Osaka Univ. Graduate School of Medicine) ,  SATO Yoshifumi (Dep. of Metabolic Medicine, Osaka Univ. Graduate School of Medicine) ,  SHIMOMURA Iichirou (Dep. of Metabolic Medicine, Osaka Univ. Graduate School of Medicine) ,  IKEGAMI Hiroshi (Dep. of Endocrinology, Metabolism and Diabetes, Kinki Univ. School of Medicine) ,  RAKUGI Hiromi (Dep. of Geriatric Medicine, Osaka Univ. Graduate School of Medicine)
Material： Endocrine Journal  (Endocr J)
Volume： 56  Issue： 2  Page： 227-234 (J-STAGE)  Publication year： 2009 
JST Material Number： F0625A  ISSN： 0918-8959  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Fatty Liver ,...
Semi thesaurus term： *non-insulin-dependent diabetes mellitus ,...

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JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Basic medicine on digestive system  (GH01020E)

Reference (17)：

• RHODES, CJ. Type 2 diabetes-a matter of beta-cell life and death?. Science. 2005, 307, 380-384
• MEIER, JJ. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes. 2008, 57, 1584-1594
• BAGUST, A. Deteriorating beta-cell function in type 2 diabetes : a long-term model. Qjm. 2003, 96, 281-288
• OYAMA, K. Spontaneous recovery from hyperglycemia by regeneration of pancreatic beta-cells in Kir6.2G132S transgenic mice. Diabetes. 2006, 55, 1930-1938
• RACHDI, L. Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner. Proc Natl Acad Sci USA. 2008, 105, 9250-9255

Terms in the title (5)： 2型糖尿病 ,  非アルコール性脂肪性肝疾患 ,  マウスモデル ,  細胞量 ,  糖尿病