Art

J-GLOBAL ID：200902281079528340   Reference number：03A0109528

Core Structure in Roselipins Essential for Eliciting Inhibitory Activity against Diacylglycerol Acyltransferase.

ジアシルグリセロールアシルトランスフェラーゼ阻害活性の発現に必須なロセリピンのコア構造

Author (4)： TOMODA H (Kitasato Univ., Tokyo, JPN) ,  TABATA N ,  OHYAMA Y ,  OMURA S (Kitasato Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 56  Issue： 1  Page： 24-29  Publication year： Jan. 25, 2003 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *acyltransferase ,...
Semi thesaurus term： diacylglycerol acyltransferase ,...

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JST classification (3)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Basic research of antibiotics acting on pathogenic organisms  (GX05020C) ,  Other natural substances of biological origin  (CF10090R)

Substance index (8)： Roselipin 1A ,  Roselipin 1B ,  Roselipin 2A ,  Roselipin 2B ,  Roselipin 3A ,  Roselipin 3B ,  Roselipin 4 ,  Roselipin 5

Reference (11)：

• 1) OMURA, S.; H. TOMODA, Y. OHYAMA, N. TABATA, T. ABE & M. NAMIKOSHI: Roselipins, novel fungal metabolites having a highly methylated fatty acid modified with a mannose and an arabinitol. J. Antibiotics 52: 586-589, 1999
• 2) TOMODA, H.; Y. OHYAMA, T. ABE, N. TABATA, M. NAMIKOSHI, Y. YAMAGUCHI, R. MASUMA & S. OMURA: Roselipins, inhibitors of diacylglycerol acyltransferase produced by Gliocladium roseum KF-1040. J. Antibiotics 52: 689-694, 1999
• 3) TABATA, N.; Y. OHYAMA, H. TOMODA, T. ABE, M. NAMIKOSHI & S. OMURA: Structure elucidation of roselipins, inhibitors of diacylglycerol acyltransferase produced by Gliocladium roseum KF-1040. J. Antibiotics 52: 815-826, 1999
• 4) MAYOREK, N. & J. BAR-TANA: Inhibition of diacylglycerol acyltransferase by 2-bromooctanoate in cultured rat hepatocytes. J. Biol. Chem. 260: 6528-6532, 1985
• 5) TOMODA, H.; K. IGARASHI, J.-C. CYONG & S. OMURA: Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation.-Inhibition of long chain aryl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation. J. Biol. Chem. 266: 4214-4219, 1991

Terms in the title (4)： ジアシルグリセロールアシルトランスフェラーゼ ,  阻害活性 ,  発現 ,  コア構造