Art

J-GLOBAL ID：200902286411042270   Reference number：09A0029158

Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-α, and COX-2 expression in mouse macrophage RAW 264.7

マウスマクロファージRAW264.7における炎症メディエーターiNOS,TNF-αおよびCOX-2発現に対するタイの薬用植物Clausena guillauminiiから単離したオキシクマリン類の抑制効果

Author (9)： NAKAMURA Tomonori (Chiba Univ., Chiba, JPN) ,  KODAMA Naoko (Chiba Univ., Chiba, JPN) ,  ARAI Yu (Chiba Univ., Chiba, JPN) ,  KUMAMOTO Takuya (Chiba Univ., Chiba, JPN) ,  HIGUCHI Yoshihiro (Shiratori Pharmaceutical Co., Ltd., Chiba, JPN) ,  CHAICHANTIPYUTH Chaiyo (Chulalongkorn Univ., Bangkok, THA) ,  ISHIKAWA Tsutomu (Chiba Univ., Chiba, JPN) ,  UENO Koichi (Chiba Univ., Chiba, JPN) ,  YANO Shingo (Chiba Univ., Chiba, JPN)
Material： Journal of Natural Medicines  (J Nat Med)
Volume： 63  Issue： 1  Page： 21-27  Publication year： 2009 
JST Material Number： L5856A  ISSN： 1340-3443  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： Clausena guillauminii ,...

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JST classification (2)： Pharmacology in general  (GW01000B) ,  Enzyme in general  (EB09010D)

Substance index (4)： Heptaphylline ,  Osthol ,  Xanthoxyletin ,  7-Methoxyheptaphylline

Reference (24)：

• AKAIKE, T. Nitric oxide and virus infection. Immunology. 2000, 101, 300-308
• BRUCH-GERHARZ, D. A proinflammatory activity of interleukin 8 in human skin : expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes. J Exp Med. 1996, 184, 2007-2012
• KOLB, H. Nitric oxide in autoimmune disease : cytotoxic or regulatory mediator?. Immunol Today. 1998, 19, 556-561
• SUSCHEK, CV. The role of iNOS in chronic inflammatory processes in vivo : is it damage-promoting, protective, or active at all?. Curr Mol Med. 2004, 4, 763-775
• HOSOKAWA, A. A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression. Chem Pharm Bull (Tokyo). 2004, 52, 1265-1267

Terms in the title (12)： マウス ,  マクロファージ ,  炎症メディエーター ,  iNOS ,  TNF-α ,  COX-2 ,  発現 ,  タイ ,  薬用植物 ,  Clausena ,  単離 ,  抑制効果