Art

J-GLOBAL ID：200902291411030853   Reference number：09A0905081

Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS

c-Met/HGF受容体のセリン残基およびチロシン残基の疾病依存性相互的リン酸化はALSのトランスジェニックマウスモデルの疾患遅延に寄与する

Author (8)： KADOYAMA Keiichi (Div. of Molecular Regenerative Medicine, Dep. of Biochemistry and Molecular Biology, Osaka Univ. Graduate School of ...) ,  KADOYAMA Keiichi (Div. of Pharmacology, Fac. of Pharmaceutical Sciences, Himeji Dokkyo Univ., Himeji 670-8524, JPN) ,  FUNAKOSHI Hiroshi (Div. of Molecular Regenerative Medicine, Dep. of Biochemistry and Molecular Biology, Osaka Univ. Graduate School of ...) ,  OHYA-SHIMADA Wakana (Div. of Molecular Regenerative Medicine, Dep. of Biochemistry and Molecular Biology, Osaka Univ. Graduate School of ...) ,  NAKAMURA Takahiro (Div. of Tumor Dynamics and Regulation, Cancer Res. Inst., Kanazawa Univ., Kanazawa 920-0934, JPN) ,  MATSUMOTO Kunio (Div. of Tumor Dynamics and Regulation, Cancer Res. Inst., Kanazawa Univ., Kanazawa 920-0934, JPN) ,  MATSUYAMA Shogo (Div. of Pharmacology, Fac. of Pharmaceutical Sciences, Himeji Dokkyo Univ., Himeji 670-8524, JPN) ,  NAKAMURA Toshikazu (Kringle Pharma Joint Res. Div. for Regenerative Drug Discovery, Center for Advanced Sci. and Innovation, Osaka Univ. ...)
Material： Neuroscience Research  (神経科学)
Volume： 65  Issue： 2  Page： 194-200  Publication year： Oct. 2009 
JST Material Number： D0210C  ISSN： 0168-0102  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： oncoprotein ,...
Semi thesaurus term： *c-met ,...

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JST classification (3)： Basic neurology  (GN01020W) ,  Biological function  (EB03040U) ,  Peripheral nervous system  (EJ12020U)

Reference (23)：

• Andreozzi, F., Melillo, R.M., Carlomagno, F., Oriente, F., Miele, C., Fiory, F., Santopietro, S., Castellone, M.D., Beguinot, F., Santoro, M., Formisano, P., 2003. Protein kinase Cα activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase. Oncogene 22, 2942-2949.
• Cleveland, D.W., Rothstein, J.D., 2001. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat. Rev. Neurosci. 2, 806-819.
• Ebens, A., Brose, K., Leonardo, E.D., Hanson Jr., M.G., Bladt, F., Birchmeier, C., Barres, B.A., Tessier-Lavigne, M., 1996. Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. Neuron 17, 1157-1172.
• Funakoshi, H., Nakamura, T., 2003. Hepatocyte growth factor: from diagnosis to clinical applications. Clin. Chim. Acta 327, 1-23.
• Gandino, L., Longati, P., Medico, E., Prat, M., Comoglio, P.M., 1994. Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase. J. Biol. Chem. 269, 1815-1820.

Terms in the title (10)： c-met ,  HGF受容体 ,  セリン残基 ,  チロシン残基 ,  疾病 ,  依存性 ,  リン酸化 ,  ALS ,  疾患 ,  遅延