Art

J-GLOBAL ID：201002235684862731   Reference number：10A1099888

Significance of Advanced Glycation End Products in Aging-Related Disease

老化関連疾患における高度糖化最終産物の意義

Author (5)： NAGAI Ryoji (Dep. of Food and Nutrition, Lab. of Biochemistry and Nutritional Sci., Japan Women’s Univ.) ,  MORI Takefumi (United Centers for Advanced Res. and Translational Medicine, Tohoku Univ. Graduate School of Medicine) ,  YAMAMOTO Yasuhiko (Dep. of Biochemistry and Molecular Vascular Biology, Kanazawa Univ. Graduate School of Medical Sci.) ,  KAJI Yuichi (Dep. of Ophthalmology, Univ. of Tsukuba Inst. of Clinical Medicine) ,  YONEI Yoshikazu (Anti-Aging Medical Res. Center, Graduate School of Life and Medical Sciences, Doshisha Univ.)
Material： Anti-Aging Medicine (Web)  (Anti Aging Med (Web))
Volume： 7  Issue： 10  Page： 112-119 (J-STAGE)  Publication year： 2010 
JST Material Number： U0079A  ISSN： 1882-2762  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *senile change ,...
Semi thesaurus term： AGEs ,...

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JST classification (4)： Geriatrics  (GC09000X) ,  Biological function  (EB03040U) ,  Eye diseases  (GP03000U) ,  Urogenital diseases  (GM03000L)

Substance index (4)： Aminoguanidine ,  Glucose ,  Pyridoxamine ,  Benfotiamine

Reference (68)：

• 1) Monnier VM, Kohn RR, Cerami A: Accelerated age-related browning of human collagen in diabetes mellitus Proc Natl Acad Sci U S A 81; 583-587: 1984
• 2) Mera K, Takeo K, Izumi M, et al: Effect of reactive-aldehydes on the modification and dysfunction of human serum albumin. J Pharm Sci 99; 1614-1625: 2010
• 3) Nagai R, Matsumoto K, Ling X, et al: Glycolaldehyde, a reactive intermediate for advanced glycation endproducts, plays an important role in the generation of an active ligand for the macrophage scavenger receptor. Diabetes 49; 1714-1723: 2000
• 4) Nagai R, Hayashi CM, Xia L, et al: Identification in human atherosclerotic lesions of GA-pyridine, a novel structure derived from glycolaldehyde-modified proteins. J Biol Chem 277; 48905-48912: 2002
• 5) McLellan AC: Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications. Clin Sci (London) 87; 21-29: 1994

Terms in the title (3)： 老化 ,  疾患 ,  高度糖化最終産物