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J-GLOBAL ID：201002247190631271   Reference number：10A0163152

Up-regulation of Survivin by the E2A-HLF Chimera Is Indispensable for the Survival of t(17;19)-positive Leukemia Cells

E2A-HLFキメラによるサーバイビンの上方制御がt(17;19)陽性白血病細胞の生存に必須である

Author (14)： OKUYA Mayuko (Dokkyo Medical Univ. School of Medicine, Tochigi, JPN) ,  KUROSAWA Hidemitsu (Dokkyo Medical Univ. School of Medicine, Tochigi, JPN) ,  KIKUCHI Jiro (Jichi Medical School, Tochigi, JPN) ,  FURUKAWA Yusuke (Jichi Medical School, Tochigi, JPN) ,  MATSUI Hirotaka (Hiroshima Univ., Hiroshima, JPN) ,  AKI Daisuke (Hiroshima Univ., Hiroshima, JPN) ,  MATSUNAGA Takayuki (Dokkyo Medical Univ. School of Medicine, Tochigi, JPN) ,  INUKAI Takeshi (Univ. Yamanashi School of Medicine, Yamanashi, JPN) ,  GOTO Hiroaki (Yokohama City Univ. School of Medicine, Kanagawa, JPN) ,  ALTURA Rachel A. (Warren Alpert Medical School of Brown Univ., Rhode Island) ,  SUGITA Kenich (Dokkyo Medical Univ. School of Medicine, Tochigi, JPN) ,  ARISAKA Osamu (Dokkyo Medical Univ. School of Medicine, Tochigi, JPN) ,  LOOK A.Thomas (Dana-Farber Cancer Inst., Massachusetts) ,  INABA Toshiya (Hiroshima Univ., Hiroshima, JPN)
Material： Journal of Biological Chemistry  (J Biol Chem)
Volume： 285  Issue： 3  Page： 1850-1860  Publication year： Jan. 15, 2010 
JST Material Number： E0038A  ISSN： 0021-9258  CODEN： JBCHA3  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Proteins ,  Apoptosis ,  NAD(P)H oxidoreductase ,  Mitochondria ,  *B cell leukemia ,  acute leukemia ,  promoter (genetics) ,  Cell Cycle ,  genetic technique ,  *transcription factor ,  gel electrophoresis ,  fusion protein ,  DNA binding protein ,  human ,  Cell Proliferation ,  flow cytometry ,  intracellular transport ,  gene expression ,  E2A ,  RNA interference method ,  Apoptosis Inducing Factor ,  *survivin ,  Electrophoretic Mobility Shift Assay ,  dominant-negative mutation ,  nuclear translocation ,  molecular genetic phenomenon
Semi thesaurus term： B precursor type acute leukemia ,  *E2A-HLF ,  EMSA method ,  dominant negative ,  nuclear translocation

JST classification (2)： Carcinogenic mechanisms and factors  (GE02020C) ,  Cell physiology in general  (EF02010S)

Terms in the title (6)： E2A ,  キメラ ,  サーバイビン ,  上方制御 ,  白血病細胞 ,  生存