Art

J-GLOBAL ID：201002299541026914   Reference number：10A0380241

Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity

カドミウム誘発急性肝毒性に対するメタロチオネイン-IIIヌルマウスの耐性

Author (12)： HONDA Akiko (Lab. of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin Univ.) ,  HONDA Akiko (Lab. of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical Univ.) ,  KOMURO Hiroaki (Lab. of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin Univ.) ,  HASEGAWA Tatsuya (Dep. of Environmental Biochemistry, Yamanashi Inst. of Environmental Sciences) ,  SEKO Yoshiyuki (Dep. of Environmental Biochemistry, Yamanashi Inst. of Environmental Sciences) ,  SHIMADA Akinori (Dep. of Veterinary Pathology, Fac. of Agriculture, Tottori Univ.) ,  NAGASE Hisamitsu (Lab. of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical Univ.) ,  HOZUMI Isao (Dep. of Neurology and Geriatrics, Gifu Univ. Graduate School of Medicine) ,  INUZUKA Takashi (Dep. of Neurology and Geriatrics, Gifu Univ. Graduate School of Medicine) ,  HARA Hideaki (Dep. of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical Univ.) ,  FUJIWARA Yasuyuki (Lab. of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin Univ.) ,  SATOH Masahiko (Lab. of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin Univ.)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 35  Issue： 2  Page： 209-215 (J-STAGE)  Publication year： 2010 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cadmium ,...
Semi thesaurus term： メタロチオネインIII ,...

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JST classification (4)： Toxicity of metals and metal compounds  (GZ02022V) ,  Cadmium and its compounds  (SB05022I) ,  Prevention of poisoning(=intoxication)  (GZ04010Q) ,  Basic medicine on digestive system  (GH01020E)

Reference (30)：

• CARRASCO, J. Role of metallothionein-III following central nervous system damage. Neurobiol. Dis. 2003, 13, 22-36
• CEBALLOS, D. Role of metallothioneins in peripheral nerve function and regeneration. Cell Mol. Life Sci. 2003, 60, 1209-1216
• ERICKSON, J. C. Disruption of the metallothionein-III gene in mice : analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures. J. Neurosci. 1997, 17, 1271-1281
• GARRETT, S. H. Transient induction of metallothionein isoform 3 (MT-3), c-fos, c-jun and c-myc in human proximal tubule cells exposed to cadmium. Toxicol. Lett. 2002, 126, 69-80
• HABEEBU, S. S. Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium. Toxicol. Sci. 2000, 55, 223-232

Terms in the title (5)： カドミウム ,  誘発 ,  肝毒性 ,  メタロチオネイン ,  耐性