Rchr
J-GLOBAL ID：201101085132854710
Update date: Feb. 14, 2024
Hayakawa Fumihiko
ハヤカワ フミヒコ | Hayakawa Fumihiko
Affiliation and department：
Job title：
Professor
Other affiliations (2)：
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (7)：
Drug screening
, Genetic analysis
, Pathophysiological analysis
, Multi-agent clinical trial
, Clinical trial
, Malignant lymphoma
, Leukemia
Research theme for competitive and other funds (17)：
- 2018 - 現在 ALLにおける新規高頻度融合遺伝子の白血病化メカニズムの解明
- 2017 - 現在 AYA世代急性リンパ性白血病の小児型治療法および遺伝子パネル診断による層別化治療に関する研究 課題番号: 17ck0106331h0001
- 2021 - 2024 分化誘導型アイソフォーム誘導療法によるMEF2D融合遺伝子陽性白血病治療
- 2020 - 2023 フィラデルフィア染色体陽性急性リンパ性白血病に対するポナチニブを組み込んだ治療法の確立と分子基盤の解明
- 2019 - 2022 小児から成人をシームレスに対象とした B前駆細胞性急性リンパ性白血病に対する前方視的臨床試験による標準治療の開発研究
- 2018 - 2021 Investigation of molecular mechanism of new recurrent fusion genes in ALL
- 2017 - 2020 AYA世代急性リンパ性白血病の小児型治療法および遺伝子パネル診断による層別化治療に関する研究 課題番号: 17ck0106331h0001
- 2016 - 2018 成人B細胞性急性リンパ性白血病における融合遺伝子の情報に基づく分子生物学的な理解と新しい治療戦略の考案
- 2015 - 2018 Screening of therapeutic agent for Ph-positive ALL using patient-derived xenograft cells
- 2014 - 2017 AYA世代における急性リンパ性白血病の生物学的特性と小児型治療法に関する研究
- 2013 - 2016 創薬に向けた白血病のトランスレーショナルリサーチ
- 2013 - 2015 形質細胞分化運命決定におけるMAPKシグナルの役割とその破綻によるリンパ腫発症
- 2013 - 2015 悪性リンパ腫における微小環境依存性と治療開発に関する研究
- 2013 - 2014 造血器悪性腫瘍及び転移性がんで高頻度に異常を来している遺伝子を標的とした新たな治療法の開発に資する研究
- 2008 - 2011 PML の SUMO E3リガーゼ同定によるPML NB形成機構解明
- 2006 - 2008 白血病関連遺伝子産物PMLのアセチル化の意義
- 2006 - 2007 腫瘍抑制因子PMLのアセチル化による機能調節機構の解明とPML機能活性化による抗腫瘍療法
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Papers (73)：
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Shinichi Kako, Fumihiko Hayakawa, Kiyotoshi Imai, Junji Tanaka, Shuichi Mizuta, Satoshi Nishiwaki, Heiwa Kanamori, Junichi Mukae, Yukiyasu Ozawa, Tadakazu Kondo, et al. Optimal treatment for Philadelphia-negative acute lymphoblastic leukemia in first remission in the era of high-intensity chemotherapy. International journal of hematology. 2021. 114. 5. 608-619
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Takahiko Yasuda, Masashi Sanada, Masahito Kawazu, Shinya Kojima, Shinobu Tsuzuki, Hiroo Ueno, Eisuke Iwamoto, Yuka Iijima-Yamashita, Tomomi Yamada, Takashi Kanamori, et al. Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations. Blood. 2021. 139. 12. 1850-1862
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Sugiura I, Doki N, Hata T, Cho R, Ito T, Suehiro Y, Tanaka M, Kako S, Matsuda M, Yokoyama H, et al. Dasatinib-based Two-step Induction for Adults with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. Blood advances. 2021
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Yuri Hayakawa, Shogo Tamura, Nobuaki Suzuki, Koya Odaira, Mahiru Tokoro, Fumika Kawashima, Fumihiko Hayakawa, Akira Takagi, Akira Katsumi, Atsuo Suzuki, et al. Essential role of a carboxyl-terminal α-helix motif in the secretion of coagulation factor XI. Journal of thrombosis and haemostasis : JTH. 2021. 19. 4. 920-930
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Takeshi Saito, Yoshihiro Hatta, Fumihiko Hayakawa, Tsutomu Takahashi, Maki Hagihara, Hiroatsu Iida, Koichiro Minauchi, Etsuko Yamazaki, Isamu Sugiura, Tohru Murayama, et al. Combination of clofarabine, etoposide, and cyclophosphamide in adult relapsed/refractory acute lymphoblastic leukemia: a phase 1/2 dose-escalation study by the Japan Adult Leukemia Study Group. International journal of hematology. 2021. 113. 3. 395-403
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MISC (52)：
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Hirano Daiki, Hayakawa Fumihiko, Yasuda Takahiko, Tange Naoyuki, Yamamoto Hideyuki, Kojima Yuki, Morishita Takanobu, Imoto Naoto, Tsuzuki Shinobu, Mano Hiroyuki, et al. Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity. ONCOGENE. 2019. 38. 13. 2263-2274
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Li Jian-Feng, Dai Yu-Ting, Lilljebjorn Henrik, Shen Shu-Hong, Cui Bo-Wen, Bai Ling, Liu Yuan-Fang, Qian Mao-Xiang, Kubota Yasuo, Kiyoi Hitoshi, et al. Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018. 115. 50. E11711-E11720
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Sakamoto A, Kunou S, Shimada K, Tsunoda M, Aoki T, Iriyama C, Tomita A, Nakamura S, Hayakawa F, Kiyoi H. Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells. Cancer science. 2018
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Tanaka Y, Kawazu M, Yasuda T, Tamura M, Hayakawa F, Kojima S, Ueno T, Kiyoi H, Naoe T, Mano H. Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia. Haematologica. 2018. 103. 11. e522-e526
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Shimada K, Hayakawa F, Kiyoi H. Biology and management of primary effusion lymphoma. Blood. 2018. 132. 18. 1879-1888
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Lectures and oral presentations (6)：
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Treatment of acute lymphoblastic leukemia in adolescent and young adult by pediatric protocols.
(2016)
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New molecular targets of B-cell acute lymphoblastic leukemia
(2016)
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Genetic abnormalities of AYA ALL and its treatment strategy by pediatric like protocols.
(2016)
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Adolescent and young adult (AYA)世代の急性リンパ性白血病
(第77回日本血液学会学術集会 2015)
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AYA ALL に対する小児プロトコールの有効性と認容の検討:JALSG ALL202-U 研究より
(第56回日本小児血液・がん学会学術集会シンポジウム 2014)
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Education (1)：
- 1987 - 1993 Nagoya University Faculty of Medicine
Professional career (1)：
Work history (12)：
- 2020/04/01 - 現在 Nagoya University Graduate School of Medicine Professor
- 2018/04/01 - 現在 Nagoya University Graduate School of Medicine, Department of Radiological and Medical Laboratory Sciences
- 2016/05/01 - 現在 Nagoya University Hospital, Hospital
- 2018/04/01 - 2020/03/31 Nagoya University Graduate School of Medicine Department of Radiological and Medical Laboratory Sciences Pathophysiological Laboratory Sciences Professor
- 2015/05/01 - 2018/03/31 Nagoya University Nagoya University Hospital Hematology Lecturer
- 2010/04/01 - 2015/04/30 Nagoya University Nagoya University Hospital Hematology Assistant Professor
- 2008/11/01 - 2009/03/31 Nagoya University Graduate School of Medicine COE designated lecturer
- 2008/11/01 - 2009/03/31 名古屋大学医学系研究科 GCOE特任講師
- 2005/04/01 - 2008/10/31 Nagoya University Hospital
- 2004/06/01 - 2005/03/31 医師 豊橋市民病院
- 2001/05/12 - 2004/04/30 Postdoctoral fellow, Department of Microbiology, University of California, Davis
- 1993/05/15 - 1996/03/31 医師 安城更正病院
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Awards (1)：
- 2006 - 上原記念生命科学財団 上原記念生命科学財団 研究奨励金
Association Membership(s) (3)：
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