Art

J-GLOBAL ID：201902259679056645   Reference number：19A1492870

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases

1,223症例の国際的研究に基づくB細胞前駆体急性リンパ芽球性白血病の転写景観【JST・京大機械翻訳】

Author (36)： Li Jian-Feng (State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai...) ,  Dai Yu-Ting (State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai...) ,  Lilljebjorn Henrik (Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, 22184 Lund, Sweden) ,  Shen Shu-Hong (Key Laboratory of Pediatric Hematology and Oncology, Ministry of Health, Department of Hematology and Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, 200127 Shanghai, China) ,  Cui Bo-Wen (State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai...) ,  Bai Ling (State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai...) ,  Liu Yuan-Fang (State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai...) ,  Qian Mao-Xiang (Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN 38105) ,  Kubota Yasuo (Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 1138654 Tokyo, Japan) ,  Kiyoi Hitoshi (Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 4668550 Nagoya, Japan) ,  Matsumura Itaru (Division of Hematology and Rheumatology, Kinki University Faculty of Medicine, 5778502 Osaka, Japan) ,  Miyazaki Yasushi (Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, 8528521 Nagasaki, Japan) ,  Olsson Linda (Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, 22184 Lund, Sweden) ,  Tan Ah Moy (Department of Paediatrics, KK Women’s & Children’s Hospital, 229899 Singapore) ,  Ariffin Hany (Paediatric Haematology-Oncology Unit, University of Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia) ,  Chen Jing (Key Laboratory of Pediatric Hematology and Oncology, Ministry of Health, Department of Hematology and Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, 200127 Shanghai, China) ,  Takita Junko (Department of Pediatrics, Graduate School of Medicine, Kyoto University, 6068501 Kyoto, Japan) ,  Yasuda Takahiko (Clinical Research Center, Nagoya Medical Center, National Hospital Organization, 4600001 Nagoya, Japan) ,  Mano Hiroyuki (National Cancer Center Research Institute, 1040045 Tokyo, Japan) ,  Johansson Bertil (Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, 22184 Lund, Sweden) ,  Johansson Bertil (Department of Clinical Genetics, University and Regional Laboratories, Region Skane, Lund 22185, Sweden) ,  Yang Jun J. (Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN 38105) ,  Yang Jun J. (Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105) ,  Yeoh Allen Eng-Juh (Centre for Translational Research in Acute Leukaemia, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 119228 Singapore) ,  Hayakawa Fumihiko (Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, 4618673 Nagoya, Japan) ,  Chen Zhu (State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai...) ,  Chen Zhu (Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China) ,  Chen Zhu (Pole de Recherches Sino-Francais en Science du Vivant et Genomique, Laboratory of Molecular Pathology, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China) ,  Pui Ching-Hon (Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105) ,  Fioretos Thoas (Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, 22184 Lund, Sweden) ,  Fioretos Thoas (Department of Clinical Genetics, University and Regional Laboratories, Region Skane, Lund 22185, Sweden) ,  Chen Sai-Juan (State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai...) ,  Chen Sai-Juan (Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China) ,  Chen Sai-Juan (Pole de Recherches Sino-Francais en Science du Vivant et Genomique, Laboratory of Molecular Pathology, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China) ,  Huang Jin-Yan (State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200025 Shanghai...) ,  Huang Jin-Yan (Pole de Recherches Sino-Francais en Science du Vivant et Genomique, Laboratory of Molecular Pathology, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 115  Issue： 50  Page： E11711-E11720  Publication year： 2018 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Most B cell precursor acute ly...

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Thesaurus term： human ,  characterization ,  Heredity ,  Mutation ,  Prognosis ,  chromosome ,  gene expression ,  Transcriptome ,  stratification ,  child ,  adult (person) ,  *RNA ,  ZEB2 ,  Runx1 ,  molecular genetic phenomenon
Semi thesaurus term： サブタイプ ,  *急性リンパ性白血病 , 【Automatic Indexing@JST】

Author keywords (5)： BCP ALL ,  RNA-seq ,  subtypes ,  gene fusion ,  gene mutation

JST classification (3)： Gene expression  (EC02040Q) ,  Biological function  (EB03040U) ,  Blood cell tumors(=neoplasms)  (GK04000M)

Terms in the title (7)： 症例 ,  研究 ,  B細胞 ,  前駆体 ,  急性リンパ芽球性白血病 ,  転写 ,  景観