Art

J-GLOBAL ID：201102250856820307   Reference number：11A1242079

Stereoselective Synthesis of Core Structure of Cortistatin A

コルチスタチンAのコア構造の立体選択的合成

Author (3)： KOTOKU Naoyuki (Osaka Univ., Osaka, JPN) ,  SUMII Yuji (Osaka Univ., Osaka, JPN) ,  KOBAYASHI Motomasa (Osaka Univ., Osaka, JPN)
Material： Organic Letters  (Org Lett)
Volume： 13  Issue： 13  Page： 3514-3517  Publication year： Jul. 01, 2011 
JST Material Number： W1171A  ISSN： 1523-7060  CODEN： ORLEF7  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,  *stereospecific reaction ,  steroid alkaloid ,  pharmacological action ,  coupling reaction ,  Heck reaction ,  cyclization reaction ,  Michael reaction ,  retrosynthetic analysis ,  angiogenesis inhibitory effect ,  *stereoselective synthesis
Semi thesaurus term： antiangiogenic effect ,  *stereoselective synthesis

JST classification (2)： Cyclization reaction,ring-opening reaction  (CF02050I) ,  Addition reaction,elimination reaction  (CF02030M)

Substance index (22)： Cortistatin A ,  2-(tert-Butyldimethylsiloxymethyl)-2-cyclohexene-1-one ,  (1R)-2-(tert-Butyldimethylsiloxymethyl)-2-cyclohexene-1β-ol ,  (6β)-1β-(tert-Butyldimethylsiloxymethyl)-7-oxabicyclo[4.1.0]heptane-2-one ,  (6β)-1β-(tert-Butyldimethylsiloxymethyl)-2-hydroxy-7-oxabicyclo[4.1.0]heptane-2β-acetic acid tert-butyl ester ,  (6β)-1β-(tert-Butyldimethylsiloxymethyl)-2-(methoxymethoxy)-7-oxabicyclo[4.1.0]heptane-2β-ethanol ,  (6β)-1β-(tert-Butyldimethylsiloxymethyl)-2β-(2-iodoethyl)-2-(methoxymethoxy)-7-oxabicyclo[4.1.0]heptane ,  1β-(Methoxymethoxy)-7aβ-methyl-2,3,5,6,7,7a-hexahydro-1H-indene-5-one ,  (1S)-1β-(Methoxymethoxy)-4-[2-[(6β)-1β-(tert-butyldimethylsiloxymethyl)-2-(methoxymethoxy)-7-oxabicyclo[4.1.0]heptane-2β-yl]ethyl]-7aβ-methyl-2,3,5,6,7,7a-hexahydro-1H-indene-5-one ,  (1S)-1β-(Methoxymethoxy)-4-[2-[(6β)-1β-(tert-butyldimethylsiloxymethyl)-2-(methoxymethoxy)-7-oxabicyclo[4.1.0]heptane-2β-yl]ethyl]-5-(tert-butyldimethylsiloxy)-7aβ-methyl-2,3,3aα,6,7,7a-hexahydro-1H-indene ,  (1S,3aα)-1β-(Methoxymethoxy)-4α-[2-[(6β)-1β-(tert-butyldimethylsiloxymethyl)-2-(methoxymethoxy)-7-oxabicyclo[4.1.0]heptane-2β-yl]ethyl]-7aβ-methyloctahydro-1H-indene-5-one ,  (1S,3aα)-1β-(Methoxymethoxy)-4α-[2-[(1S)-1-(methoxymethoxy)-2-methylene-3β-hydroxycyclohexane-1α-yl]ethyl]-7aβ-methyloctahydro-1H-indene-5-one ,  (1S)-1β-(Methoxymethoxy)-4-[2-[(1S)-1-(methoxymethoxy)-2-methylene-3β-(tert-butyldiphenylsiloxy)cyclohexane-1α-yl]ethyl]-5-(trifluoromethylsulfonyloxy)-7aβ-methyl-2,3,3aα,6,7,7a-hexahydro-1H-indene-6-one ,  4-[2-[1β-(Methoxymethoxy)-2-methylene-3β-(tert-butyldiphenylsiloxy)cyclohexyl]ethyl]-5-(trifluoromethylsulfonyloxy)-6β-acetoxy-1β-(methoxymethoxy)-7aβ-methyl-2,3,3aα,6,7,7a-hexahydro-1H-indene ,  4-[2-[1β-(Trimethylsiloxy)-2-methylene-3β-(tert-butyldiphenylsiloxy)cyclohexyl]ethyl]-5-(trifluoromethylsulfonyloxy)-6β-acetoxy-1β-(methoxymethoxy)-7aβ-methyl-2,3,3aα,6,7,7a-hexahydro-1H-indene ,  1α-(tert-Butyldiphenylsiloxy)-5,17β-bis(methoxymethoxy)-11β-acetoxy-9,10-seco-9,19-cyclo-5α-androsta-8,10(19)-diene ,  1α-(tert-Butyldiphenylsiloxy)-5-(trimethylsiloxy)-11β-acetoxy-17β-(methoxymethoxy)-9,10-seco-9,19-cyclo-5α-androsta-8,10(19)-diene ,  1α-(tert-Butyldiphenylsiloxy)-5,17β-bis(methoxymethoxy)-11β-acetoxy-9,10-seco-9,19-cyclo-5α-androsta-7,9(19)-diene ,  1α-(tert-Butyldiphenylsiloxy)-5-(trimethylsiloxy)-11β-acetoxy-17β-(methoxymethoxy)-9,10-seco-9,19-cyclo-5α-androsta-7,9(19)-diene ,  1α-(tert-Butyldiphenylsiloxy)-5-hydroxy-17β-(methoxymethoxy)-9,10-seco-9,19-cyclo-5α-androsta-8,10(19)-diene-11-one ,  (9S)-1α-(tert-Butyldiphenylsiloxy)-17β-(methoxymethoxy)-5,8α-epoxy-9,10-seco-9,19-cyclo-5α-androsta-10(19)-ene-11-one ,  1α-(tert-Butyldiphenylsiloxy)-17β-(methoxymethoxy)-5,8α-epoxy-9,10-seco-9,19-cyclo-5α-androsta-9(11),10(19)-diene

Terms in the title (3)： コルチスタチンA ,  コア構造 ,  立体選択的合成