Rchr
J-GLOBAL ID：200901044210527694   Update date: Nov. 11, 2024

NAOYUKI KOTOKU

コトク ナオユキ | NAOYUKI KOTOKU
Affiliation and department：
Ritsumeikan University College of Pharmaceutical Sciences, Department of Pharmacy

About Ritsumeikan University College of Pharmaceutical Sciences, Department of Pharmacy


Job title： Professor
Homepage URL  (1)： https://www.ritsumei.ac.jp/pharmacy/chemicalbiology/index.html
Research field  (4)： Environmental and pharmaceutical development resources ,  Pharmaceuticals - chemistry and drug development ,  Chemical biology ,  Molecular biochemistry
Research keywords  (1)： Synthetic organic chemistry, Natural Products chemistry, Medicinal chemistry, Chemical biology
Research theme for competitive and other funds  (21)：
  • 2022 - 2025 海洋天然物を起点とする膵臓ガン選択的増殖阻害剤の創製と薬剤耐性メカニズム解明
  • 2021 - 2024 接着分子内在化を機序とする抗体創薬の基礎研究
  • 2018 - 2022 Mechanistic studies of tumor cell growth using marine natural product and its application for anti-tumor drug discovery
  • 2017 - 2019 統合的戦略に基づく新規PPI阻害剤の創製
  • 2015 - 2018 Medicinal chemistry study of bioactive marine natural products targeting tumor microenvironment
Show all
Papers (59)：
  • Yurina Mihara, Haruki Kadoya, Soki Kakihana, Naoyuki Kotoku. Concise and Stereospecific Total Synthesis of Arenastatin A and Its Segment B Analogs. Molecules. 2024
  • Yo Kiichi, Koshiro Fukuoka, Anna Kitano, Koya Ishino, Naoyuki Kotoku. Unified Synthesis and Biological Evaluation of Makaluvamine J and Its Analogs. Molecules. 2024
  • Yuki Nakatani, Risa Kimura, Tomoyo Kimata, Naoyuki Kotoku. Oxidative Cyclization at ortho-Position of Phenol: Improved Total Synthesis of 3-(Phenethylamino)demethyl(oxy)aaptamine. Marine drugs. 2023. 21. 5
  • Junya Mukomura, Hiroki Nonaka, Hiromasa Sato, Maho Kishimoto, Masayoshi Arai, Naoyuki Kotoku. Anti-Mycobacterial N-(2-Arylethyl)quinolin-3-amines Inspired by Marine Sponge-Derived Alkaloid. Molecules (Basel, Switzerland). 2022. 27. 24
  • Yuji Sumii, Kentaro Kamiya, Takehiko Nakamura, Kenta Tanaka, Takumi Kaji, Junya Mukomura, Naoyuki Kotoku, Masayoshi Arai. Study of the Structure-Activity Relationship of an Anti-Dormant Mycobacterial Substance 3-(Phenethylamino)Demethyl(oxy)aaptamine to Create a Probe Molecule for Detecting Its Target Protein. Marine drugs. 2022. 20. 2
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MISC (5)：
Patents (3)：
  • 抗がん物質のスクリーニング方法
  • Preparation of cortistatin A-analog compounds for inhibiting vascular endothelial cell growth and angiogenesis
  • Preparation of prenylarene compounds for use as anticancer agents
Lectures and oral presentations  (6)：
  • Synthetic study of novel analogs of arenastatin A
    (139th Annual Meeting of the Pharmaceutical Society of Japan 2019)
  • Synthesis and Mechanistic Studies of Biakamides, Naturally-occurring Anti-austerity Agents Targeting Mitochondria
    (4th International Symposium for Medicinal Sciences (ISMS) 2018)
  • 海洋天然物を基盤とする潜在性結核菌に有効な新規抗菌剤シーズの合成
    (第67回日本薬学会近畿支部総会・大会 2017)
  • 栄養飢餓環境選択的がん細胞増殖阻害活性物質biakamide類の合成研究と作用機序解析
    (第59回天然有機化合物討論会 2017)
  • 有機合成化学を基盤とする海洋天然物のケミカルバイオロジー研究
    (第37回有機合成若手セミナー「明日の有機合成を担う人のために」 2017)
ｍore...
Education (3)：
  • - 2003 Osaka University Graduate School of Pharmaceutical Sciences
  • - 2000 Osaka University Graduate School of Pharmaceutical Sciences
  • - 1998 Osaka University School of Pharmacy
Professional career (1)：
  • Ph.D. (Osaka University)
Work history (5)：
  • 2024/04 - 現在 Ritsumeikan University College of Pharmaceutical Sciences Professor
  • 2017/04 - 2024/03 Associate Professor, College of Pharmaceutical Sciences, Ritsumeikan University
  • 2007/04/01 - 2017/03/31 Assistant Professor, Graduate School of Pharmaceutical Sciences, Osaka University
  • 2003/04/01 - 2007/03/31 Research Associate, School of Pharmacy, Osaka University
  • 2000/04/01 - 2003/03/31 JSPS Research Fellow
Awards (3)：
  • 2015/09 - 日本生薬学会 平成27年度日本生薬学会学術奨励賞
  • 2013/01 - 日本薬学会近畿支部 平成24年度日本薬学会近畿支部奨励賞
  • 2012/11 - 日本薬学会医薬化学部会 平成24年度日本薬学会メディシナルケミストリーシンポジウム優秀賞
Association Membership(s) (5)：
日本ケミカルバイオロジー学会 ,  日本がん分子標的治療学会 ,  有機合成化学協会 ,  日本生薬学会 ,  日本薬学会
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