Art

J-GLOBAL ID：201102257126093374   Reference number：11A0158771

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice

実験的自己免疫性脳脊髄炎マウスでのPEG化TNFR1選択的拮抗変異体TNFの治療効果

Author (21)： NOMURA Tetsuya ,  ABE Yasuhiro ,  KAMADA Haruhiko ,  SHIBATA Hiroko ,  KAYAMURO Hiroyuki ,  INOUE Masaki ,  KAWARA Tomoyuki ,  ARITA Shuhei ,  FURUYA Takeshi ,  YAMASHITA Takuya ,  NAGANO Kazuya ,  YOSHIKAWA Tomoaki ,  YOSHIOKA Yasuo ,  MUKAI Yohei ,  NAKAGAWA Shinsaku ,  TANIAI Madoka ,  OHTA Tsunetaka ,  SERADA Satoshi ,  NAKA Tetsuji ,  TSUNODA Shin-ichi ,  TSUTSUMI Yasuo
Material： Journal of Controlled Release  (J Control Release)
Volume： 149  Issue： 1  Page： 8-14  Publication year： Jan. 05, 2011 
JST Material Number： C0308D  ISSN： 0168-3659  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： *TNFR1選択的拮抗薬 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=11A0158771&from=J-GLOBAL&jstjournalNo=C0308D") }}

JST classification (1)： Cytokines  (EB08090G)

Reference (24)：

• K. Hohnoki, A. Inoue, C.S. Koh, Elevated serum levels of IFN-gamma, IL-4 and INF-alpha/unelevated serum levels of IL-10 in patients with demyelinating diseases during the acute stage, J. Neuroimmunol. 87 (1998) 27-32.
• Sigrid R. Ruuls, Robert M. Hoek, Vu N. Ngo, Tom McNeil, Linda A. Lucian, Mary J. Janatpour, Heinrich Körner, Heleen Scheerens, Edith M. Hessel, Jason G. Cyster, Leslie M. McEvoy, Jonathon D. Sedgwick, Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation, Immunity 15 (2001) 533-543.
• N. Mohan, E.T. Edwards, T.R. Cupps, P.J. Oliverio, G. Sandberg, H. Crayton, J.R. Richert, J.N. Siegel, Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides, Arthritis Rheum. 44 (2001) 2862-2869.
• TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group, Neurology 53 (1999) 457-465.
• N.L. Sicotte, R.R. Voskuhl, Onset of multiple sclerosis associated with anti-TNF therapy, Neurology 57 (2001) 1885-1888.

Terms in the title (8)： 実験的自己免疫性脳脊髄炎 ,  マウス ,  PEG化 ,  TNFR1 ,  拮抗 ,  変異体 ,  TNF ,  治療効果