Art

J-GLOBAL ID：201102259836726034   Reference number：11A1644685

Effect of Efonidipine on TGF-β1-Induced Cardiac Fibrosis Through Smad2-Dependent Pathway in Rat Cardiac Fibroblasts

ラット心臓線維芽細胞におけるSmad2依存性経路を介するTGF-β1-誘導心臓線維症に対するエホニジピンの効果

Author (11)： LEI Bai (Dep. of Pharmacology, Fac. of Medicine, Kagawa Univ., JPN) ,  HITOMI Hirofumi (Dep. of Pharmacology, Fac. of Medicine, Kagawa Univ., JPN) ,  MORI Tatsuhiko (Dep. of Internal Medicine III, Osaka Medical Coll., JPN) ,  NAGAI Yukiko (Life Sciences Res. Center, Fac. of Medicine, Kagawa Univ., JPN) ,  DEGUCHI Kazushi (Dep. of Gastroenterology and Neurology, Fac. of Medicine, Kagawa Univ., JPN) ,  MORI Hirohito (Dep. of Gastroenterology and Neurology, Fac. of Medicine, Kagawa Univ., JPN) ,  MASAKI Tsutomu (Dep. of Gastroenterology and Neurology, Fac. of Medicine, Kagawa Univ., JPN) ,  NAKANO Daisuke (Dep. of Pharmacology, Fac. of Medicine, Kagawa Univ., JPN) ,  KOBORI Hiroyuki (Dep. of Pharmacology, Fac. of Medicine, Kagawa Univ., JPN) ,  KITAURA Yasushi (Dep. of Internal Medicine III, Osaka Medical Coll., JPN) ,  NISHIYAMA Akira (Dep. of Pharmacology, Fac. of Medicine, Kagawa Univ., JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 117  Issue： 2  Page： 98-105 (J-STAGE)  Publication year： 2011 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *TGF beta ,...
Semi thesaurus term： Calcium Channels, L-Type ,...

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JST classification (1)： Basic research of cardioactive drugs  (GW07020N)

Substance index (1)： Efonidipine

Reference (38)：

• 1 Akiyama-Uchida Y, Ashizawa N, Ohtsuru A, Seto S, Tsukazaki T, Kikuchi H, et al. Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts. Hypertension. 2002;40:148–154.
• 2 Takeda N, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, et al. Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest. 2010;120:254–265.
• 3 Nagamatsu Y, Nishida M, Onohara N, Fukutomi M, Maruyama Y, Kobayashi H, et al. Heterotrimeric G protein G alpha13-induced induction of cytokine mrnas through two distinct pathways in cardiac fibroblasts. J Pharmacol Sci. 2006;101:144–150.
• 4 Eghbali M, Tomek R, Sukhatme VP, Woods C, Bhambi B. Differential effects of transforming growth factor-beta 1 and phorbol myristate acetate on cardiac fibroblasts. Regulation of fibrillar collagen mrnas and expression of early transcription factors. Circ Res. 1991;69:483–490.
• 5 Sigel AV, Centrella M, Eghbali-Webb M. Regulation of proliferative response of cardiac fibroblasts by transforming growth factor-beta 1. J Mol Cell Cardiol. 1996;28:1921–1929.

Terms in the title (9)： ラット ,  心臓線維芽細胞 ,  Smad2 ,  依存性 ,  経路 ,  TGF-β1 ,  誘導 ,  心臓線維症 ,  エホニジピン